川北医学院学报2026，Vol.41Issue(1)：77-82,6.DOI:10.3969/j.issn.1005-3697.2026.01.016
瑞芬太尼在成人体外循环心脏手术中通过调节NF-κB信号通路介导的炎症反应改善凝血功能的作用
Remifentanil improves coagulation function by modulating the inflammatory response mediated by NF-κB signaling pathway in adult cardiopulmonary bypass surgery
摘要
Abstract
Objective:To study the role of remifentanil in improving coagulation function by regulating the inflammatory response mediated by the NF-κB signaling pathway in adult cardiopulmonary bypass cardiac surgery.Methods:The research subjects were 204 adult patients who underwent cardiopulmonary bypass cardiac surgery.They were divided into two groups based on different intervention methods.The patients in the study group received targeted remifentanil infusion anesthesia,while those in the control group received intermittent sufentanil infusion anesthesia.The differences in hemodynamic indicators,surgical indicators,inflammatory response,stress response,coagulation function,NF-κB signaling pathway and complications were compared between the two groups.Results:The differences in HR,MAP,CVP,CCI,SVV,PAP,SPO2 and BIS at different time points between the two groups were statistically significant(P<0.05).The cardiopulmonary bypass time,operation time,sufentanil dosage and propofol dosage in the study group were all lower than those in the control group,and the aortic cross-blocking time was higher than that in the control group(P<0.05).After the operation,The inflammatory indicators in both groups were significantly increased.The levels of IL-6 and TNF-α in the study group were lower than those in the control group(P<0.05),and IL-10 was higher than that in the control group(P<0.05).The oxidative stress indicators in both groups were significantly increased,and the levels of ACTH,Cor and C3a in the study group were lower than those in the control group(P<0.05).The coagulation functions of both groups fluctuated.Moreover,the TT,APTT and PT in the study group were all lower than those in the control group(P<0.05).The NF-κB signaling pathway indicators in both groups improved,and the P50,P65,Act1 and IκBα in the study group were all lower than those in the control group(P<0.05).There was no statistically significant difference in complications between the two groups(P>0.05).Conclusion:Remifentanil regulates the NF-κB signaling pathway,influencing the expression of P65,P50,Act1 and IκBα proteins,reducing the release of inflammatory factors,and improving coagulation function.This demonstrates the advantages of remifentanil in analgesia and its significant role in postoperative immune regulation and the recovery of coagulation function.关键词
瑞芬太尼/NF-κB信号通路/体外循环/凝血功能/炎症反应Key words
Remifentanil/NF-κB signaling pathway/Cardiopulmonary bypass/Coagulation function/Inflammatory response分类
医药卫生引用本文复制引用
刘晓宁,王岩英,王洋,赵成秀,王春阳..瑞芬太尼在成人体外循环心脏手术中通过调节NF-κB信号通路介导的炎症反应改善凝血功能的作用[J].川北医学院学报,2026,41(1):77-82,6.基金项目
河北省邯郸市科学技术研究与发展计划项目(23422083255) （23422083255）
