Abstract
Objective:To investigate the correlation between triglyceride glucose-body mass index(TyG-BMI)and the comorbidity of metabolic-associated fatty liver disease(MAFLD)in patients with chronic kidney disease(CKD).Methods:A total of 250 hospitalized CKD patients were enrolled.Patients were divided into two groups based on the presence or absence of MAFLD:CKD alone group(n=125)and CKD with MAFLD group(n=125).Differences in baseline characteristics and TyG-BMI levels between groups were compared.TyG-BMI was stratified into four quartiles,and the incidence of MAFLD across these quartiles was analyzed.Pearson correlation analysis was used to assess the relationship between TyG-BMI and various clinical parameters.Logistic regression was performed to evaluate the independent association between TyG-BMI and MAFLD risk in CKD patients.Receiver operating characteristic(ROC)curve analysis was conducted to determine the predictive value of TyG-BMI for MAFLD occurrence.Results:Compared to the CKD alone group,the CKD with MAFLD group exhibited higher levels of diabetes prevalence,BMI,lymphocytes(LYM),monocytes(MONO),hemoglobin(HB),high-sensitivity C-reactive protein(Hs-CRP),total bilirubin(TBil),direct bilirubin(DBil),serum creatinine(Cr),triglycerides(TG),GGT/HDL,LDL-C/HDL-C,monocyte-to-HDL ratio(MHR),atherogenic index of plasma(AIP),TyG,TyG-BMI,and TyG-ALT,while albumin(ALB),estimated glomerular filtration rate(eGFR),and HDL levels were lower,with statistically significant differences(P<0.05).As the staging of CKD progresses,the prevalence of MAFLD showed an increasing trend(P<0.05).Stratification of TyG-BMI into quartiles showed MAFLD incidence rates of 3.2%,25.6%,30.4%,and 40.8%in Q1 to Q4 groups,respectively,indicating an increasing trend with higher TyG-BMI levels,intergroup differences were statistically significant(P<0.001).Pearson correlation analysis revealed positive correlations between TyG-BMI and BMI,HB,TG,Cr,LDL-C/HDL-C,AIP,TyG,and TyG-ALT(P<0.05),and negative correlations with DBil,ALB,HDL-C,and eGFR(P<0.05).After adjusting for confounders such as age,sex,hypertension,diabetes,HB,GGT/HDL-C,MHR,LDL-C/HDL-C,and TyG-ALT,Logistic regression indicated that TyG-BMI was an independent risk factor for MAFLD in CKD patients(OR=1.12,95%CI=1.07～1.16,P<0.001).ROC analysis showed an area under the curve(AUC)of 0.720(95%CI:0.656～0.784)for TyG-BMI in predicting MAFLD,with an optimal cutoff value of 215.25,sensitivity of 63.0%,and specificity of 90.0%.Conclusion:In CKD patients,the risk of MAFLD may increase with rising TyG-BMI levels;TyG-BMI could serve as an independent risk factor and a valuable predictive biomarker for MAFLD in this population.关键词
三酰甘油葡萄糖-体质量指数/慢性肾脏病/代谢相关脂肪性肝病Key words
Triglyceride glucose-body mass index/Chronic kidney disease/Metabolic-associated fatty liver disease分类
医药卫生
