摘要
Abstract
Objective:To explore the efficacy of Seretide and Breztri Aerosphere inhalation in the treatment of patients with asthma-chronic obstructive pulmonary disease overlap syndrome(ACOS).Methods:103 patients with ACOS were selected as study subjects,and were divided into Seretide group(n=52)and Breztri Aerosphere group(n=51)according to different treatment regimens.Patients in Seretide group were treated with Seretide,while patients in the Breztri Aerosphere group received Breztri Aerosphere treatment.The course of treatment was 90 days.The clinical efficacy,disease control status[chronic obstructive pulmonary disease score(CAT),asthma control score(ACT)],improvement of lung function[forced expiratory volume in one second(FEV1),forced vital capacity(FVC),inspiratory fraction(IC/TLC)],immune changes in T lymphocytes[helper T cell 17(Th17),regulatory T cell(Treg)],serum indicators[interleukin 17(IL-17),eosinophil count(EOS)],occurrence of adverse reactions and disease progression were compared between the two groups of patients.Results:The clinical efficacy in Breztri Aerosphere group was better than that in Seretide group(P<0.05).After treatment,the CAT score and levels of FeNO,Th17,EOS and IL-17 in the two groups of patients were decreased(P<0.05),and Breztri Aerosphere group showed lower score and levels compared to Seretide group(P<0.05).The ACT score and levels of FEV1,FVC,IC/TLC and Treg were increased in both groups,and Breztri Aerosphere group had higher score and levels than those in Seretide group(P<0.05).There was no statistical difference in the incidence of adverse reactions between the two groups(P>0.05).The acute exacerbation rate and emergency visit rate in Breztri Aerosphere group were lower than those in Seretide group(P<0.05).Conclusion:Breztri Aerosphere can improve the pulmonary function and immune function in patients with ACOS,and has high safety,which is worth promoting and applying.关键词
布地格福/沙美特罗替卡松/哮喘慢阻肺重叠综合征/肺功能Key words
Budesonide,glycopyrronium bromide and formoterol fumarate/Salmeterol fluticasone/Asthma-chronic obstructive pulmonary disease overlap syndrome/Pulmonary function分类
医药卫生
