工业微生物2025，Vol.55Issue(6)：37-42,6.DOI:10.3969/j.issn.1001-6678.2025.06.012
叶黄素酯的微囊化制备、吸收利用及抗蓝光研究
Research on the Microencapsulation Preparation,Absorption and Utilization,and Blue-light Resistance of Lutein Esters
张潇童 1任翔 1于倩倩 1耿佳鑫 1吴文忠 1范超1
作者信息
- 1. 大连医诺生物股份有限公司,辽宁 大连 116600
- 折叠
摘要
Abstract
Lutein ester is a class of carotenoid fatty acid esters with multiple biological activities and health benefits,but its susceptibility to oxidation and poor water solubility lead to poor stability and bioavailability in the human body.This study used spray drying technology to prepare lutein ester microcapsule powder and used Caco-2 cells to examine the cell uptake of lutein and compare the bioavailability of different formulations.It also established a blue light-induced retinal damage model in mice to examine the protective effect of microencapsulated lutein esters against blue light exposure compared to non-encapsulated forms.The bioavailability of lutein ester microcapsule powder and zeaxanthin microcapsule powder in rats was investigated by 1:1 compounding,and the anti-blue light protective effect of the compound microcapsule powder was studied by using the blue light-induced retinal damage model in mice.The study found that the relative bioavailability of lutein ester microcapsule powder in vitro was 3.8 times that of the crystal,and it produced effective anti-blue light effects in mice.The relative bioavailability of lutein ester:zeaxanthin=1:1 microcapsule powder in rats was 186.803%compared with the raw material group.Compared with standalone lutein ester microcapsules,the combined microcapsule powder demondtrated enhanced blue-light protection,and it showed a significant advantage in the activity of GSH-PX and T-SOD compared to groups using lutein ester or zeaxanthin alone.关键词
叶黄素酯/微囊化/玉米黄质/生物利用度/抗蓝光Key words
lutein ester/microencapsulation/zeaxanthin/bioavailability/anti-blue light引用本文复制引用
张潇童,任翔,于倩倩,耿佳鑫,吴文忠,范超..叶黄素酯的微囊化制备、吸收利用及抗蓝光研究[J].工业微生物,2025,55(6):37-42,6.
