中国妇幼健康研究2026，Vol.37Issue(1)：67-73,7.DOI:10.3969/j.issn.1673-5293.2026.01.010
妊娠晚期孕妇血清尿素氮/肌酐比值与妊娠并发症及胎儿体重的关系研究
Association of maternal serum BUN/Cr ratio in late pregnancy with pregnancy complications and fetal weight
摘要
Abstract
Objective This study aimed to examine the association between the maternal blood urea nitrogen(BUN)to creatinine(Cr)ratio during late pregnancy and the occurrence of pregnancy complications as well as fetal birth weight.Methods A total of 2 286 pregnant women with≥28 weeks of gestation who were admitted to the Women and Children's Hospital of Ningbo University between September 2024 and December 2024 were enrolled.Fasting serum BUN and Cr levels were measured upon admission.Participants were categorized into three groups according to their serum BUN/Cr ratio:<15.0(n=1 001),15.0-19.9(n=740),and≥20.0(n=545).The incidences of hypertensive disorders complicating pregnancy(HDCP),gestational diabetes mellitus(GDM),hypothyroidism,oligohydramnios,preterm birth,and fetal growth restriction(FGR),as well as fetal birth weight,were compared across groups.Correlation analysis was performed to assess the relationship between maternal BUN/Cr ratio and fetal birth weight.Results Significant differences were observed in the incidence of HDCP among the three groups(χ2=265.582,P<0.05),with the highest incidence noted in the≥20.0 group and the lowest in the<15.0 group.The incidence of GDM was highest in the BUN/Cr≥20.0 group and lowest in the BUN/Cr<15.0 group(χ2=27.066,P<0.05).The≥20.0 group also showed higher rates of hypothyroidism,oligohydramnios,and preterm birth compared with the other two groups(χ2=34.246,7.175 and 42.680,respectively P<0.05).The incidence of FGR differed significantly among groups(χ2=118.618,P<0.05),being highest in the≥20.0 group and lowest in the<15.0 group(P<0.05).Fetal birth weight also varied significantly(F=58.715,P<0.05),with the≥20.0 group exhibiting the lowest birth weight.After adjusting for confounders,the group with highter maternal BUN/Cr ratio remained an independent risk factor for FGR(OR=1.222,95%CI:1.182-1.263),and it was negatively correlated with fetal birth weight(r=-0.301,P<0.05).Conclusion An elevated maternal serum BUN/Cr ratio in late pregnancy is associated with a higher risk of pregnancy complications and lower fetal birth weight.The maternal BUN/Cr ratio may serve as a potential biomarker for predicting adverse pregnancy outcomes and low birth weight.关键词
妊娠晚期/并发症/出生体重/尿素氮/肌酐Key words
late pregnancy/complication/birth weight/urea nitrogen/creatinine分类
医药卫生引用本文复制引用
周旭平,张孝认,冯永贤,张百蕾..妊娠晚期孕妇血清尿素氮/肌酐比值与妊娠并发症及胎儿体重的关系研究[J].中国妇幼健康研究,2026,37(1):67-73,7.基金项目
宁波市卫生健康科技计划项目(2022Y15) （2022Y15）
浙江省医药卫生科技计划项目(2024KY1571) （2024KY1571）
