河北中医2026，Vol.48Issue(1)：42-47,6.DOI:10.3969/j.issn.1002-2619.2026.01.009
非高密度脂蛋白胆固醇/高密度脂蛋白胆固醇与2型糖尿病患者肝脏脂肪含量的相关性
Correlation of non-high-density lipoprotein cholesterol/high-density lipoprotein cholesterol radio with liver fat content in patients with type 2 diabetes mellitus
摘要
Abstract
Objective The aim of this study was to investigate the association between non-high-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio(NHHR)and liver fat content in patients with type 2 diabetes mellitus(T2DM)and to analyze the differences in this association in different age subgroups(<60 and≥60 years)of T2DM patients.Methods The study included 481 patients with T2DM,who were divided into two subgroups:(i)low NHHR group(n=240)and high NHHR group(n=241)based on the median NHHR;and(ii)<60 years old group(n=204 and≥60 years old group(n=277)based on age.The influencing factors of liver fat content were analyzed by univariate linear regression,and then the independent correlation between NHHR and liver fat content was analyzed by four multivariate linear regression models.Results The high-NHHR group had significantly higher blood glucose,blood lipids,liver fat content,a greater proportion of males with younger age,and had significantly shorter duration of diabetes(all P<0.05).In the<60year group,diabetes duration was significantly shorter(P<0.05),the proportion of males was significantly higher(P<0.05),and quantitatively measured liver fat was significantly greater(P<0.05).Univariate regression showed that liver fat content was negatively correlated with age and diabetes duration(P<0.05)and positively correlated with NHHR(P<0.01).The factors influencing liver fat content differed across age groups.Multivariate regression,adjusting for confounders,indicated that NHHR was significantly and positively associated with liver fat content in patients with T2DM(P<0.05).This association was significant only in the≥60year group(P<0.001)and was not significant in the<60 year group(P>0.05).Conclusion Elevated NHHR may be associated with increased liver fat content in patients with T2DM,and the association is more pronounced in T2DM patients≥60 years of age.关键词
2型糖尿病/非高密度脂蛋白胆固醇/高密度脂蛋白胆固醇/肝脏脂肪含量Key words
Type 2 diabetes mellitus/Non-high-density lipoprotein cholesterol/High-density lipoprotein cholesterol/Liver fat content分类
医药卫生引用本文复制引用
高海娜,朱立影,张培,宋媛,高琳辉..非高密度脂蛋白胆固醇/高密度脂蛋白胆固醇与2型糖尿病患者肝脏脂肪含量的相关性[J].河北中医,2026,48(1):42-47,6.基金项目
河北省卫生健康委员会科研计划项目(编号:20201348) （编号:20201348）
