河北中医2026，Vol.48Issue(1)：52-56,61,6.DOI:10.3969/j.issn.1002-2619.2026.01.011
调气化浊法治疗慢性阻塞性肺疾病急性加重期合并2型糖尿病痰瘀互结兼气阴两虚证临床研究
摘要
Abstract
Objective To observe the clinical effect of regulating gasification and turbidity on acute exacerbation of chronic obstructive pulmonary disease(AECOPD)patients with type 2 diabetes mellitus(T2DM)in the syndrome of phlegm and blood stasis plus Qi and Yin deficiencies.Methods A total of 96 AECOPD patients with T2DM in the syndrome of phlegm and blood stasis plus Qi and Yin deficiencies treated in the Department of Pulmonary Diseases(68 cases)and Department of Diabetes(28 cases)of Huaibei Hospital of Traditional Chinese Medicine from October 2022 and December 2023 were included.They were randomly divided into the treatment group and control group,with 48 cases in each group.Patients in both groups received routine Western medicine treatment,while those in the treatment group additionally received Chaiting Ningfei Granules and Danzhi Jiangtang Capsules.The TCM syndrome scores,lung function,blood gas analysis,blood glucose indicators,the fear of progression questionnaire--short form in Chinese version(FoP-Q-SF),the COPD Assessment Test(CAT),and safety indicators were compared between the two groups before and after treatment.Results After treatment,TCM syndrome,FoP-Q-SF and CAT scores,and blood sugar indicators(glycated hemoglobin[HbA1c],fasting plasma glucose[FPG],and 2 h postprandial blood sugar[2 hPG])were significantly reduced in both groups(P<0.05),which were significantly lower in the treatment group than the control group(P<0.05).After treatment,the forced vital capacity(FVC),forced expiratory volume in the first second(FEV1),and FEV1/FVC were significantly elevated in both groups(P<0.05),which were significantly higher in the treatment group than the control group(P<0.05).After treatment,significantly higher oxygen partial pressure(PaO2)and oxygen saturation(SaO2),and lower carbon dioxide partial pressure(PaCO2)were detected in both groups(P<0.05),which were significantly pronounced in the treatment group than the control group(P<0.05).No adverse reactions occurred during the clinical trial in both groups.Conclusion For AECOPD patients with T2DM,regulating gasification and turbidity can effectively improve lung function,blood gas indexes,blood sugar indexes,quality of life and TCM syndrome scores,and with high safety.关键词
肺疾病,慢性阻塞性/糖尿病,2型/痰瘀互结/气阴两虚/调气化浊法Key words
Chronic obstructive pulmonary disease/Type 2 diabetes mellitus/Phlegm and blood stasis/Qi and Yin deficiencies/Regulating gasification and turbidity分类
医药卫生引用本文复制引用
郑彩霞,方朝晖,于盼,程若东,许成群,朱雪娜..调气化浊法治疗慢性阻塞性肺疾病急性加重期合并2型糖尿病痰瘀互结兼气阴两虚证临床研究[J].河北中医,2026,48(1):52-56,61,6.基金项目
2022年度安徽省卫生健康科研项目(编号:AHWJ2022b115) （编号:AHWJ2022b115）
2022年度安徽省博士后科研人员科研活动经费资助项目(编号:2022B586) （编号:2022B586）
2022年度安徽省中医药传承创新科研项目(编号:2022CCYB17) （编号:2022CCYB17）
安徽中医药大学2021年度临床科研项目(编号:2021LCHB02) （编号:2021LCHB02）
