激光生物学报2025，Vol.34Issue(6)：496-503,8.DOI:10.3969/j.issn.1007-7146.2025.06.003
端粒长度检测方法的研究进展
The Advancement of Telomere Length Measurement Methods
摘要
Abstract
Telomeres are specialized structures at the ends of chromosomes,composed of repetitive DNA sequences and associated proteins.Their primary role is to maintain chromosomal stability and integrity by preventing progressive loss of chromosome ends and unwanted chromosomal rearrangements.Changes in telomere length are closely linked to a variety of diseases,including cancer,aging,and cardiovascular disorders.Therefore,measuring telomere length holds significant biological importance.Driven by technological advances,a diverse array of methods for telomere-length assessment has emerged,forming a rich technical landscape.Each method carries distinct advantages and limitations,making it suitable for particular research goals and application contexts.This review summarizes current findings on all major telomere-measurement techniques and offers recommendations for future technological development,emphasizing the potential of integrating innovative approaches to enhance disease diagnosis and treatment strategies,providing researchers and clinicians with a guide for selecting optimal methods and facilitating the translation of telomere biology into precise diagnostics and personalized therapies.关键词
端粒长度/检测方法/细胞衰老/生物标志物/精准诊断Key words
telomere length/detection methods/cellular senescence/biomarker/accurate diagnosis分类
生物科学引用本文复制引用
刘律君,谢舜,刘晓雯,刘敏,毛增辉,邓爱民..端粒长度检测方法的研究进展[J].激光生物学报,2025,34(6):496-503,8.基金项目
湖南省临床医疗技术创新引导项目(2021SK53204) （2021SK53204）
湖南省卫健委科研计划项目(B202305036567) （B202305036567）
湖南省卫健委科研计划项目(202205033875). （202205033875）
