激光生物学报2025，Vol.34Issue(6)：515-522,529,9.DOI:10.3969/j.issn.1007-7146.2025.06.005
乳酸-乳酸化轴调控肿瘤免疫微环境
Lactate-lactylation Axis Regulates the Tumor Immune Microenvironment
摘要
Abstract
Lactate has long been regarded as a metabolic byproduct of glycolysis.Recent studies,however,have revealed its pivotal role in regulating the tumor immune microenvironment(TIME).Excess lactate accumulation disrupts metabolic balance,suppresses the activity of T cells and NK cells,and induces the polarization of immunosuppressive cells,thereby reshaping the immune landscape of TIME.Meanwhile,lactylation,as a novel post-translational protein modification,mediates the regulation of epigenetic events by metabolic signals,promoting the expression of immune-related genes,such as PD-L1,IL-10,and Arg1,and further enhancing immune evasion.This review focuses on the metabolic-epigenetic coordination of lactate and lactylation in TIME,elaborating on lactate production and shuttling,immune-cell metabolic interactions,and the clinical potential of targeting lactate homeostasis.A deeper understanding of the lactate-lactylation axis may provide novel molecular targets and research directions for future tumor immunotherapy.关键词
乳酸/乳酸化/肿瘤代谢/免疫调控/治疗耐药Key words
lactate/lactylation/tumor metabolism/immune regulation/therapeutic resistance分类
医药卫生引用本文复制引用
薛文迪,李雄..乳酸-乳酸化轴调控肿瘤免疫微环境[J].激光生物学报,2025,34(6):515-522,529,9.基金项目
国家自然科学基金项目(81572542,81874096) （81572542,81874096）
广东药科大学学科培优项目重点团队-自然科学类(2024ZZ10). （2024ZZ10）
