激光生物学报2025，Vol.34Issue(6)：541-550,576,11.DOI:10.3969/j.issn.1007-7146.2025.06.008
基于图像配准和自适应窗口方向衬比的眼底散斑流成像
Fundus Speckle Flow Imaging Based on Image Registration and Adaptive Window Directional Contrast
摘要
Abstract
In the monitoring,diagnosis,and clinical management of fundus diseases,the visualization of fundus vascular structures is recognized as of paramount importance for accurate pathological assessment.Laser speckle contrast imaging,a well-established non-invasive optical imaging technique,is capable of achieving vessel visualization and real-time dynamic blood flow monitoring,as contrast agents are not required.However,significant noise is inevitably introduced by the conventional contrast calculation method that employs a fixed-size sliding window.In the present study,laser speckle contrast images are aligned and fused with vascular structural images acquired via LED light illumination.Subsequent to fusion,the composite images are segmented into regional subsets,and region-specific optimal pixels are selected based on the variance criterion to perform contrast computation.Within the vascular boundary region,the geometry and dimensions of the analysis window are dynamically adjusted to adapt to the local vascular morphology.The results indicate that the contrast has been enhanced by 67.61%.Moreover,in deeper vascular imaging,the proposed method is found to yield superior noise reduction performance and enhanced image quality,thereby providing support for the diagnosis and management of ocular diseases.关键词
激光散斑衬比成像/眼底/血流/图像配准/自适应窗口Key words
laser speckle contrast imaging/fundus/blood flow/image registration/adaptive window分类
医药卫生引用本文复制引用
王佳,李一鸣,武文昌,周传清,杨晖..基于图像配准和自适应窗口方向衬比的眼底散斑流成像[J].激光生物学报,2025,34(6):541-550,576,11.基金项目
上海市教育委员会人工智能项目(SHJWAIJK241201) （SHJWAIJK241201）
国家自然科学基金项目(12372384). （12372384）
