中国实用神经疾病杂志2025，Vol.28Issue(12)：1471-1475,5.DOI:10.12083/SYSJ.250222
基于HR-VWI的OPN E-选择素及Ang-Ⅱ与颅内动脉瘤的相关性研究
HR-VWI-based association study of OPN,E-selectin,and angiotensin Ⅱ in intracranial aneurysms
摘要
Abstract
Objective To investigate the associations of osteopontin(OPN),E-selectin,and angiotensinⅡ(Ang-Ⅱ)with intracranial aneurysms(IA)and their potential value for instability assessment within high-resolution vessel wall imaging(HR-VWI)framework.Methods In this retrospective case-control study,47 patients with IA and 40 healthy controls were included.IA cases were further stratified by HR-VWI mural enhancement into unstable group(marked wall enhancement)and stable group(no wall enhancement).After an overnight fast,morning venous blood was collected,and plasma OPN,E-selectin,and Ang-Ⅱ levels were measured by ELISA,and the biomarker levels were compared between the IA group and the control group,as well as between the unstable group and the stable group.Results Compared with the control group,the IA group showed higher OPN levels(t=2.65,P=0.009),while E-selectin and Ang-Ⅱ did not differ significantly(P>0.05).Within the IA cohort,none of the three biomarkers differed significantly between the unstable group and the stable group(P>0.05).Conclusion OPN is elevated in IA and is associated with IA occurrence.In this sample,OPN,E-selectin,and Ang-Ⅱ showed limited independent discriminative value for assessing aneurysm instability.Larger cohorts with longitudinal follow-up are warranted.关键词
颅内动脉瘤/高分辨率磁共振血管壁成像/骨桥蛋白/E-选择素/血管紧张素2/血浆Key words
Intracranial aneurysm/High-resolution magnetic resonance vessel wall imaging/Osteopontin/E-selectin/AngiotensinⅡ/Plasma分类
医药卫生引用本文复制引用
赵锐,崔树兰,邬刚,马鹏程,周瑞..基于HR-VWI的OPN E-选择素及Ang-Ⅱ与颅内动脉瘤的相关性研究[J].中国实用神经疾病杂志,2025,28(12):1471-1475,5.基金项目
云南省高层次卫生健康技术人才培养专项经费资助项目(编号:H-2024078) （编号:H-2024078）
昆明市卫生科技人才培养项目[编号:2022-SW(带头)-24,2024-SW(带头)-11] （带头）
