集成技术2026，Vol.15Issue(1)：1-13,13.DOI:10.12146/j.issn.2095-3135.20250630002
单细胞多模态组学技术原理及应用
Principles and Applications of Single-Cell Multimodal Omics Technologies
摘要
Abstract
Single-cell multimodal omics technologies have emerged as a revolutionary approach in the life sciences,overcoming the limitations of traditional bulk-cell studies and single-modal omics focusing on isolated analyses.These cutting-edge techniques enable simultaneous interrogation of multiple molecular layers-including genome,transcriptome,epigenome,and proteome-at single-cell resolution.This review provides a comprehensive overview of the fundamental principles,methodological features,and broad biomedical applications of single-cell multimodal omics.We first introduce the basic concepts of these technologies,followed by detailed explanations of key technical principles underlying genome-transcriptome co-profiling,epigenome-transcriptome joint sequencing,and proteome-transcriptome integrated analysis.Furthermore,we explore their applications across diverse fields such as tumor heterogeneity studies,developmental biology,neuroscience research,and precision medicine,while also discussing current technical challenges and future directions.关键词
单细胞/多模态组学/细胞图谱/生物医学研究Key words
single-cell/multimodal omics/cell atlas/biomedical research分类
生物科学引用本文复制引用
姚芳,徐志明,王利,徐舒..单细胞多模态组学技术原理及应用[J].集成技术,2026,15(1):1-13,13.基金项目
深圳市医学研究专项(A2303052) （A2303052）
中国博士后科学基金项目(2023M743677) This work is supported by Shenzhen Medical Research Fund(A2303052) （2023M743677）
China Postdoctoral Science Foundation(2023M743677) （2023M743677）
