集成技术2026，Vol.15Issue(1)：31-40,10.DOI:10.12146/j.issn.2095-3135.20250323001
介孔生物活性玻璃在靶向蛋白降解中的应用
Application of Mesoporous Bioactive Glass in Targeted Protein Degradation
摘要
Abstract
Targeted protein degradation(TPD)technologies face significant challenges,including insufficient targeting specificity and low delivery efficiency.The targeted enrichment properties of nanomaterials offer a novel strategy to overcome these bottlenecks.Mesoporous bioactive glass(MBG),renowned for its high biocompatibility and drug delivery potential,has not yet been thoroughly explored for its feasibility as a TPD vehicle.In this study,fluorescein isothiocyanate(FITC)labeling and the biotin-avidin system were employed to evaluate the subcellular localization of MBG and its potential as a protein degradation carrier.Furthermore,the ferroptosis-inducing capability of Fe-doped MBG was investigated.The results demonstrated that MBG facilitates the internalization of target proteins and degradation in lysosomes,as exemplified by the degradation of programmed cell death ligand 1.Building on this,MBG was shown to deliver iron ions into lysosomes,inducing ferroptosis.This study is the first to reveal the dual functionality of MBG in both targeted protein degradation and ferroptosis induction,providing an innovative"p rotein degradation-ferroptosis"spatiotemporally controllable synergistic strategy for cancer therapy.关键词
介孔生物活性玻璃/蛋白靶向降解/程序性死亡配体1/纳米颗粒Key words
mesoporous bioactive glass/targeted protein degradation/programmed cell death ligand 1/nanoparticles分类
生物科学引用本文复制引用
余萱,杨长江,崔旭,陈亮..介孔生物活性玻璃在靶向蛋白降解中的应用[J].集成技术,2026,15(1):31-40,10.基金项目
深圳市医学研究专项(D2301003) （D2301003）
深圳市科学技术创新委员会项目(SGDX20220530111004031,JCYJ20220818100412028) This work is supported by Shenzhen Medical Research Funds(D2301003)and Shenzhen Science and Technology Innovation Commission(SGDX20220530111004031,JCYJ20220818100412028) （SGDX20220530111004031,JCYJ20220818100412028）
