临床肝胆病杂志2025，Vol.41Issue(12)：2581-2585,5.DOI:10.12449/JCH251220
肝豆状核变性患者角膜K-F环分级与焦虑抑郁程度的相关性分析
Association between corneal Kayser-Fleischer ring grading and the degree of anxiety-depression in patients with Wilson's disease
摘要
Abstract
Objective To investigate the impact of different grades of corneal Kayser-Fleischer(K-F)ring on the severity of anxiety and depression in patients with Wilson's disease(WD).Methods A total of 107 patients with WD who received consultation in Department of Ophthalmology,The First Affiliated Hospital of Anhui University of Chinese Medicine,from August 2012 to February 2020 were enrolled,and a slit-lamp microscope was used to determine the grade of corneal K-F ring(grades 0-4).The patients were instructed to complete Hamilton Anxiety Scale(HAMA)and Hamilton Depression Scale(HAMD)assessments,and the correlation between K-F ring grade and the scores of the two scales was analyzed,as well as the differences in the scores of the two scales between the patients with different K-F ring grades.An analysis of variance was used for comparison of normally distributed continuous data between multiple groups,and the least significant difference t-test or the Dunnett's T3 test was used for further comparison between two groups;the Kruskal-Wallis H test was used for comparison of non-normally distributed continuous data between multiple groups,and the Bonferroni method was used for further comparison between two groups.The Spearman correlation analysis was used to investigate the correlation between K-F ring grade and HAMA/HAMD score.Results Among the 107 patients with WD,the patients with grade 0 K-F ring accounted for the lowest proportion of 4.6%(5/107),while the patients with grade 4 K-F ring accounted for the highest proportion of 41.1%(44/107),and the patients with grade 1 K-F ring,grade 2 K-F ring,and grade 3 K-F ring accounted for 16.8%(18/107),22.4%(24/107),and 14.9%(16/107),respectively.HAMA and HAMD scores tended to increase with the increase in K-F ring grade(F=16.340 and 12.760,both P<0.001).The Spearman correlation analysis showed that K-F ring grade was positively correlated with HAMA and HAMD scores(r=0.528 9 and 0.480 1,both P<0.01).Conclusion There is a certain correlation between corneal K-F ring grading and HAMD/HAMA scores,which can partially reflect the severity of anxiety and depression in patients.Therefore,clinicians should emphasize K-F ring examination and its association with clinical symptoms.关键词
肝豆状核变性/汉密尔顿焦虑量表/汉密尔顿抑郁量表/焦虑Key words
Hepatolenticular Degeneration/Hamilton Anxiety Scale/Hamilton Depression Scale/Anxiety引用本文复制引用
李慧,何伟,黄学海,陈义..肝豆状核变性患者角膜K-F环分级与焦虑抑郁程度的相关性分析[J].临床肝胆病杂志,2025,41(12):2581-2585,5.基金项目
国家自然科学基金(区域创新发展联合基金)(U22A20366) National Natural Science Foundation of China(Joint Fund for Regional Innovation and Development)(U22A20366) （区域创新发展联合基金）
