兰州大学学报（医学版）2025，Vol.51Issue(11)：68-74,7.DOI:10.13885/j.issn.2097-681X.2025.11.010
鼻咽癌筛查研究进展
Progress in screening nasopharyngeal carcinoma
摘要
Abstract
Nasopharyngeal carcinoma's occult anatomical location and a lack of specific symptoms in early stages,implementing effective early screening strategies remains crucial for improving a patient's overall sur-vival and quality of life.Although Epstein-Barr virus-based serological testing has been widely implemented in endemic regions of China,its clinical utility is currently constrained by a suboptimal positive predictive value and specificity.With recent breakthroughs in high-throughput molecular biology and artificial intelli-gence,nasopharyngeal carcinoma screening paradigms are undergoing a shift from single-modality serologi-cal indicators toward multi-omics,multi-modal and precision-based approaches.This review systematically summarized the technical evolution of novel biomarkers represented by P85-Ab,multi-dimensional risk mod-els and AI-aided diagnosis in the early identification of nasopharyngeal carcinoma,optimization of popula-tion risk stratification and clinical decision-making.Furthermore,by integrating health economic evaluations of different screening pathways,this article provided scientific evidence and strategic support for constructing a hierarchical,cost-effective and precise screening architecture.关键词
鼻咽癌/筛查/Epstein-Barr病毒/人工智能/风险分层/卫生经济学评价Key words
nasopharyngeal carcinoma/screening/Epstein-Barr virus/artificial intelligence/risk stratification/health economic evaluation分类
医药卫生引用本文复制引用
刘帆,俞霞,熊磊,李廷栋,季明芳..鼻咽癌筛查研究进展[J].兰州大学学报（医学版）,2025,51(11):68-74,7.基金项目
国家自然科学基金面上资助项目(8247120793) （8247120793）
中山市社会公益与基础研究重大资助项目(2023B3008) （2023B3008）
