南通大学学报（自然科学版）2025，Vol.24Issue(4)：85-94,10.DOI:10.12194/j.ntu.20241207001
基于活性氧生成/消除机制的纳米平台的临床应用及研究进展
Clinical application and research progress of nanoplatform based on reactive oxygen generation/elimination mechanism
李妍琪 1周逢春 1沈唯一 1施文君 1王梦凡2
作者信息
- 1. 南通大学 化学化工学院,江苏南通 226019
- 2. 苏州大学能源学院,江苏 苏州 215031
- 折叠
摘要
Abstract
Reactive oxygen species(ROS)are key molecules ubiquitous in cellular metabolic processes,extensively participating in the regulation of various physiological functions.As important signaling molecules,ROS not only me-diate the regulation of biological growth and development but are also closely related to the health status and aging process of organisms,serving as indispensable biochemical fundamental elements for maintaining normal life activities.This is also the important basis for ROS regulation applications in clinical medicine.Breakthrough advances in nano-technology have catalyzed the development of a series of nanomaterials with precise ROS regulation functions.These materials can directionally regulate the ROS dynamic balance in biological microenvironments,laying the material foundation for novel therapeutic paradigms based on ROS concentration regulation.The core of this therapeutic strate-gy lies in:achieving the ternary cascade synergy of"nano-regulation-ROS response-therapeutic output"through nano-material-mediated spatiotemporal control of ROS levels.ROS regulation is considered an emerging discipline with the intersection of chemical mechanisms,biological effects,and nano-therapy applications.This review provides a detailed summary of recent research progress in ROS regulation-based nano-therapies,focusing on the potential chemical components of nanomaterials that elevate or decrease ROS levels through generation or scavenging effects to improve therapeutic outcomes,aiming to help researchers unlock more ROS-based nanomaterial application approaches and therapeutic methods.关键词
活性氧/氧化应激/肿瘤治疗/抗菌性能/炎症处理Key words
reactive oxygen species/oxidative stress/tumor therapy/antibacterial performance/inflammation treatment分类
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李妍琪,周逢春,沈唯一,施文君,王梦凡..基于活性氧生成/消除机制的纳米平台的临床应用及研究进展[J].南通大学学报（自然科学版）,2025,24(4):85-94,10.
