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Integrative omics and multi-cohort identify IRF1 and biological targets related to sepsis-associated acute respiratory distress syndrome

Jiajin Chen David C.Christiani Feng Chen Ruyang Zhang Ruili Hou Xiaowen Xu Ning Xie Jiaqi Tang Yi Li Xiaoqing Nie Nuala J.Meyer Li Su

生物医学研究杂志（英文版）2026，Vol.40Issue(1)：11-22,12.

生物医学研究杂志（英文版）2026，Vol.40Issue(1)：11-22,12.DOI:10.7555/JBR.39.20250066

Integrative omics and multi-cohort identify IRF1 and biological targets related to sepsis-associated acute respiratory distress syndrome

Jiajin Chen ¹David C.Christiani ²Feng Chen ³Ruyang Zhang ⁴Ruili Hou ³Xiaowen Xu ³Ning Xie ³Jiaqi Tang ³Yi Li ⁵Xiaoqing Nie ⁶Nuala J.Meyer ⁷Li Su⁸

作者信息

1. Institute of Cardiovascular Diseases,Xiamen Cardiovascular Hospital of Xiamen University,Xiamen University School of Medicine,Xiamen,Fujian 361006,China||Department of Biostatistics,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China||China International Cooperation Center for Environment and Human Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China
2. Department of Environmental Health,Harvard T.H.Chan School of Public Health,Boston,MA 02115,USA||Pulmonary and Critical Care Division,Department of Medicine,Massachusetts General Hospital and Harvard Medical School,Boston,MA 02114,USA
3. Department of Biostatistics,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China||China International Cooperation Center for Environment and Human Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China
4. Department of Biostatistics,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China||China International Cooperation Center for Environment and Human Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China||Changzhou Medical Center,Nanjing Medical University,Changzhou,Jiangsu 213164,China
5. Department of Biostatistics,University of Michigan,Ann Arbor,MI 48109,USA
6. Institute of Cardiovascular Diseases,Xiamen Cardiovascular Hospital of Xiamen University,Xiamen University School of Medicine,Xiamen,Fujian 361006,China
7. Pulmonary,Allergy,and Critical Care Medicine Division,University of Pennsylvania Perelman School of Medicine,Philadelphia,PA 19104,USA
8. Department of Environmental Health,Harvard T.H.Chan School of Public Health,Boston,MA 02115,USA
折叠

摘要

关键词

acute respiratory distress syndrome/sepsis/interferon regulatory factor 1/causal inference/immunity

Key words

acute respiratory distress syndrome/sepsis/interferon regulatory factor 1/causal inference/immunity

分类

医药卫生

引用本文复制引用

Jiajin Chen,David C.Christiani,Feng Chen,Ruyang Zhang,Ruili Hou,Xiaowen Xu,Ning Xie,Jiaqi Tang,Yi Li,Xiaoqing Nie,Nuala J.Meyer,Li Su..Integrative omics and multi-cohort identify IRF1 and biological targets related to sepsis-associated acute respiratory distress syndrome[J].生物医学研究杂志（英文版）,2026,40(1):11-22,12.

基金项目

This study was supported by the National Natural Science Foundation of China(Grant No.82220108002 to F.C.and Grant No.82273737 to R.Z.),the U.S.National Institutes of Health(Grant Nos.CA209414,HL060710,and ES000002 to D.C.C. （Grant No.82220108002 to F.C.and Grant No.82273737 to R.Z.）

Grant Nos. CA209414 and CA249096 to Y.L.),and the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD). R.Z. was partially supported by the Qing Lan Project of the Higher Education Institutions of Jiangsu Province and the Outstanding Young Level Academic Leadership Training Program of Nanjing Medical University. （PAPD）

生物医学研究杂志（英文版）

ISSN：1674-8301

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