四川医学2025，Vol.46Issue(12)：1339-1344,6.DOI:10.16252/j.cnki.issn1004-0501-2025.12.004
可溶性ST2联合NT-ProBNP及cTnT检测对2型糖尿病患者急性冠脉综合征发生的预测价值
The Predictive Value of Soluble ST2 Combined with NT-ProBNP and cTnT in the Occurrence of ACS in Patients with Type 2 Diabetes
摘要
Abstract
Objective To investigate the predictive value of serum soluble growth stimulation gene 2 protein(sST2),a-mino-terminal brain natriuretic peptide precursor(NT-ProBNP)and cardiac troponin T(cTnT)in patients with type 2 diabetes mellitus(T2DM)complicated with acute coronary syndrome(ACS).Methods A total of 265 patients with type 2 diabetes diag-nosed in our hospital from January to December 2024 were enrolled.They were divided into T2DM group(n=198)and T2DM combined with ACS group(n=67)according to whether they were combined with ACS.40 person who underwent physical exami-nation in the health management center during the same period were collected as the control group.The relevant data of all patients were collected in detail,including but not limited to basic information such as age,gender,body mass index(BMI)and systolic blood pressure(SBP),as well as laboratory indicators such as total cholesterol(TC),serum triglyceride(TG),glycosylated hemo-globin(HbA1c)and urea(UA).Serum levels of sST2,NT-ProBNP and cTnT were further detected in the three groups.The pa-rameters of serum sST2,NT-ProBNP and cTnT were used as independent variables for Logistic regression analysis,and receiver op-erating characteristic(ROC)curve analysis was used to investigate the predictive value of the three independent and combined de-tection in patients with T2DM complicated with ACS.Results Compared with the ACS group and T2DM group,the expression lev-els of sST2,NT-ProBNP and cTnT in T2DM combined with ACS group were increased,and the differences were statistically signifi-cant(P<0.05).At the same time,there was no significant difference in serum sST2 expression between control group and T2DM group(P>0.05).In addition,Logistic regression analysis showed that serum sST2,NT-ProBNP and cTnT levels were important factors affecting the occurrence of ACS in T2DM patients,and the area under ROC curve(AUC)of the three for diagnosing T2DM combined with ACS were 0.89,0.88 and 0.90,respectively.The areas under the receiver operating characteristic(ROC)curves(AUC)for the diagnosis of T2DM with sST2 combined with NT-ProBNP and cTnT were 0.90 and0.92,respectively,with specific-ities of 97.00%and 99.50%,and sensitivities of 80.60%and 77.60%,respectively.The AUC for the combined detection of the three markers in predicting T2DM with ACS was 0.92,with a sensitivity of 77.60%and a specificity of 100%.The diagnostic val-ue of combined detection was superior to that of individual detection.Conclusion The expression levels of serum sST2,NT-ProB-NP and cTnT were elevated in the serum of T2DM patients with ACS,and the early combined detection of the three had high pre-dictive value.关键词
2 型糖尿病/急性冠脉综合征/可溶性ST2/氨基末端脑钠肽前体/心肌肌钙蛋白TKey words
T2DM/acute coronary syndrome/sST2/NT-ProBNP/cTnT分类
医药卫生引用本文复制引用
彭军容,蒋昌华,胡龙江,代小佳..可溶性ST2联合NT-ProBNP及cTnT检测对2型糖尿病患者急性冠脉综合征发生的预测价值[J].四川医学,2025,46(12):1339-1344,6.基金项目
2023年度重庆市临床重点专科建设项目 （）
重庆市涪陵区科卫联合医学科研项目(编号:2023KWLH008) （编号:2023KWLH008）
