日用化学工业（中英文）2025，Vol.55Issue(12)：1516-1525,10.DOI:10.3969/j.issn.2097-2806.2025.12.003
包裹阿伏苯宗的介孔硅稳定皮克林乳液用于增强防晒性能
Pickering emulsion stabilized by avobenzone-loaded mesoporous particles for enhanced sunscreen performance
摘要
Abstract
Organic ultraviolet(UV)filters play a crucial role in reducing sunburn,photoaging,and the risk of skin cancer induced by UV radiation.However,the challenges posed by photodegradation,potential phototoxicity,and poor dispersion characteristics of organic UV filters significantly hinder their practical applications.This study aims to encapsulate avobenzone,a widely used UV filter,in mesoporous silica(MPS)to form AB@MPS particles via an in-situ sol-gel process,and to research their sunscreen performance as stabilizers in Pickering emulsion.The UV absorption capability of AB@MPS particles is stronger than free avobenzone.The in vitro skin penetration study reveals a greatly reduced permeability(73.9%)for avobenzone from AB@MPS compared to its free form.Furthermore,the photostability of AB@MPS particles increases 14.3 times compared to that of free avobenzone.In UV protection tests,the Pickering emulsion's anti-UVA efficacy is 2.28 times greater than that of 20%PG solution,4.41 times greater than Carbomer hydrogel,and 3.59 times greater than the cream formulation.The SPF value of the Pickering emulsion is 2.41 times greater than the 20%PG solution,2 times greater than the Carbomer hydrogel,and 6.77 times greater than the cream formulation.This study presents a promising strategy for the application of Pickering emulsions in the cosmetic and pharmaceutical sectors,providing a safe and efficient formulation for sunscreens.关键词
皮克林乳液/介孔硅/防晒/光保护/润湿性Key words
Pickering emulsion/mesoporous silica/sunscreen/photoprotection/wettability分类
化学化工引用本文复制引用
黄启发,谢雯,郭晨龙,陈娟博,曾飒,孟涛..包裹阿伏苯宗的介孔硅稳定皮克林乳液用于增强防晒性能[J].日用化学工业（中英文）,2025,55(12):1516-1525,10.基金项目
国家自然科学基金资助项目(22378336) （22378336）
四川省科技厅重点研发项目(2020YFG0092,2021YFN0129) （2020YFG0092,2021YFN0129）
广州栋方生物科技股份有限公司研究基金资助(R111322H01008) （R111322H01008）
