四川医学2025，Vol.46Issue(12)：1373-1378,6.DOI:10.16252/j.cnki.issn1004-0501-2025.12.010
基于孟德尔随机化分析探讨血浆脂质与骨关节炎风险的因果联系
Causal Link Between Plasma Lipid and Osteoarthritis Risk:A Mendelian Randomization-Based Analysis
肖鹏 1黄勇 1仉贵龙 1万和伽 2魏炳琦2
作者信息
- 1. 成都中医药大学附属医院国际病房骨科,四川 成都 610075
- 2. 河南中医药大学骨伤学院,河南 郑州 450002
- 折叠
摘要
Abstract
Objective To investigate the potential causal association between plasma lipidomics and the risk of osteoar-thritis(OA)using Mendelian randomization(MR)analysis.Methods Summary statistics of genome-wide association studies(GWAS)from a Finnish population,including plasma lipidomic data from 7174 individuals,were used to identify genetic instru-mental variables associated with lipid metabolites.Five MR methods—MR-Egger regression,weighted median,inverse-variance weighted(IVW),simple mode,and weighted mode—were applied,along with Bayesian weighted analysis.Heterogeneity,pleiotro-py,and instrument bias were assessed using Cochran's Q test,MR-Egger intercept test,MR-PRESSO,and leave-one-out sensitivity analysis.Results The IVW analysis identified significant association between eight plasma lipid components and OA risk(P<0.05).No evidence of heterogeneity was detected by Cochran's Q test,andMR-PRESSOanalysis indicated no horizontal pleiotro-py.The leave-one-out analysis confirmed the robustness of individual single nucleotide polymorphisms(SNPs).Conclusion This study reveals a complex causal relationship between specific plasma lipid components and OA risk,providing a valuable insight for future research on lipid-based prevention and treatment strategies for osteoarthritis.关键词
骨关节炎/脂质/孟德尔随机化/因果推断/生物标志物/老年/临床指标Key words
osteoarthritis/lipid/Mendelian randomization/causal inference/biomarkers/old age/clinical indicators分类
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肖鹏,黄勇,仉贵龙,万和伽,魏炳琦..基于孟德尔随机化分析探讨血浆脂质与骨关节炎风险的因果联系[J].四川医学,2025,46(12):1373-1378,6.
