日用化学品科学2026，Vol.49Issue(1)：16-21,44,7.DOI:10.3969/j.issn.1006-7264.2026.01.003
纳米载体技术包裹表棓儿茶酚棓酸酯/阿魏酸/乙酰基八肽-3经皮渗透、抗氧化及抗炎作用研究
Study on the transdermal permeation,antioxidant,and anti-inflammatory effects of nanocarrier-conjugated epicatechin gallate,ferulic acid,and acetyl octapeptide-3
朱翠翠 1罗丹 2李琦 1邓军 2袁旻嘉 1刘卫3
作者信息
- 1. 上海其然生物科技有限公司,上海 201702||上海缙嘉科技有限公司,上海 201210
- 2. 武汉百思凯瑞生物科技有限公司,湖北 武汉 430075||华中科技大学 国家纳米药物工程技术研究中心,湖北 武汉 430075
- 3. 华中科技大学 国家纳米药物工程技术研究中心,湖北 武汉 430075||华中科技大学 生命科学与技术学院,湖北 武汉 430074
- 折叠
摘要
Abstract
Nanocarrier-based epicatechin gallate/ferulic acid/acetyl octapeptide-3 complexes(EFA-NCs)were prepared using nanocarrier conjugation technology.The transdermal absorption of EFA-NCs was evaluated using diffusion chamber experiments with an ex vivo porcine skin model.The antioxidant and anti-inflammatory properties were assessed through DPPH radical scavenging assays and cellular oxidative stress and inflammation models.Results demonstrated that EFA-NCs significantly enhanced the skin retention of active compounds and promoted their rapid and efficient delivery into deep dermal tissues.Antioxidant evaluations revealed that EFA-NCs effectively scavenged DPPH radicals,markedly reduced malondialdehyde(MDA)levels—a marker of oxidative damage—and increased the activities of superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px).Anti-inflammatory studies further indicated that EFA-NCs significantly inhibited the secretion of inflammatory cytokines IL-1β,IL-8,and IL-6.These findings highlight the potential of EFA-NCs as multifunctional nanocarriers for enhancing dermal delivery and improving antioxidant and anti-inflammatory performance in cosmetic and dermatological applications.关键词
表棓儿茶酚棓酸酯/阿魏酸/乙酰基八肽-3纳米载体/经皮渗透/抗炎功效/抗氧化功效Key words
epicatechin gallate/ferulic acid/acetyl octapeptide-3/nanocarrier/transdermal permeation/anti-inflammatory activity/antioxidant activity分类
化学化工引用本文复制引用
朱翠翠,罗丹,李琦,邓军,袁旻嘉,刘卫..纳米载体技术包裹表棓儿茶酚棓酸酯/阿魏酸/乙酰基八肽-3经皮渗透、抗氧化及抗炎作用研究[J].日用化学品科学,2026,49(1):16-21,44,7.
