日用化学品科学2026，Vol.49Issue(1)：22-28,7.DOI:10.3969/j.issn.1006-7264.2026.01.004
基于HaCaT和RAW264.7细胞模型的D-泛醇修护和舒缓功效机制研究
Mechanistic study of the repairing and soothing effects of D-panthenol using HaCaT and RAW264.7 cell models
田兴芳 1胡志娟 1韩婷婷 1王学文 1刘峰1
作者信息
- 1. 山东福瑞达生物股份有限公司,山东 济南 250101
- 折叠
摘要
Abstract
Barrier-repairing and anti-inflammatory mechanisms of D-panthenol using H2O2-stimulated HaCaT cells and LPS-stimulated RAW264.7 cells as in vitro models were investigated.D-panthenol at concentrations of 0.08%～0.31%and 0.08%～1.25%exhibited no cytotoxicity to HaCaT and RAW264.7 cells,respectively.Notably,treatment with 0.31%D-panthenol significantly increased the expression of FLG and TGM1 genes in H2O2-stimulated HaCaT cells by 114.79%and 66.41%,respectively.Additionally,1.25%D-panthenol markedly inhibited the release of NO,PGE2,TNF-α,IL-1β,and IL-6 in LPS-stimulated RAW264.7 cells,with inhibition rates of 28.33%,41.75%,32.82%,75.93%,and 43.83%,respectively.These findings indicate that D-panthenol enhances barrier gene expression and suppresses inflammatory mediator production at safe concentrations,supporting its potential use in skin repair and soothing applications.This study provides further theoretical evidence for the incorporation of D-panthenol in skincare formulations.关键词
D-泛醇/皮肤屏障/抗炎活性Key words
D-panthenol/skin barrier/anti-inflammatory分类
化学化工引用本文复制引用
田兴芳,胡志娟,韩婷婷,王学文,刘峰..基于HaCaT和RAW264.7细胞模型的D-泛醇修护和舒缓功效机制研究[J].日用化学品科学,2026,49(1):22-28,7.
