日用化学品科学2026，Vol.49Issue(1)：69-75,7.DOI:10.3969/j.issn.1006-7264.2026.01.010
泛醇与不同活性物协同效应研究
Study on the synergistic effect between panthenol and different active substances
牛强 1徐文枫 1莫思琪 1李适炜 1张勇军 2谢思诗2
作者信息
- 1. 广东悠质检测技术有限公司,广东 广州 510450
- 2. 广东芭薇生物科技股份有限公司,广东 广州 510450
- 折叠
摘要
Abstract
A skin barrier impairment model was established using LPS-induced RAW264.7 macrophage cells,testosterone and linoleic acid-induced sebaceous gland SZ95 cells,and tape stripping on the antecubital fossa.The synergistic inhibitory effects of panthenol and active ingredients on nitric oxide(NO)and sebum synthesis were measured,along with changes in stratum corneum hydration and transepidermal water loss rates.The results showed that 0.3%panthenol and 0.3%ectoin individually inhibited LPS-induced NO production in macrophages.When they were combined together,the better synergistic effects observed.The combination of panthenol with medicinal layer pore fungus extract and niacinamide at ratios of 0.02%,0.2%,and 0.02%exhibited superior synergistic inhibition of sebum synthesis.Within 0～6 h,the combination of panthenol and high molecular weight sodium hyaluronate demonstrated more stable moisturizing effects,where the stratum corneum hydration difference is 3.79.At 6 and 8 hours,the transepidermal water loss rates of the combination of panthenol and high molecular weight sodium hyaluronate were lower than that of other combinations,which indicated their superior skin barrier maintenance capability.关键词
泛醇/活性物/协同Key words
panthenol/active ingredients/synergistic effect分类
化学化工引用本文复制引用
牛强,徐文枫,莫思琪,李适炜,张勇军,谢思诗..泛醇与不同活性物协同效应研究[J].日用化学品科学,2026,49(1):69-75,7.
