首页|期刊导航|生物化学与生物物理学报（英文版）|Exploring the antitumor effect of curcumin-piperlongumine hybrid molecule(CP)on EGFR-TKI-resistant non-small cell lung cancer using network pharmacological analysis and experimental verification

Exploring the antitumor effect of curcumin-piperlongumine hybrid molecule(CP)on EGFR-TKI-resistant non-small cell lung cancer using network pharmacological analysis and experimental verification

Shiyu Wang Jianchang Qian Qianwen Zhang Yinshuang Lai Huijing Huang Jing Yuan Shanxin Li Min Hui Peipei Wang Bingbing Chen Zhiguo Liu

生物化学与生物物理学报（英文版）2025，Vol.57Issue(11)：1803-1813,11.

生物化学与生物物理学报（英文版）2025，Vol.57Issue(11)：1803-1813,11.DOI:10.3724/abbs.2025076

Exploring the antitumor effect of curcumin-piperlongumine hybrid molecule(CP)on EGFR-TKI-resistant non-small cell lung cancer using network pharmacological analysis and experimental verification

Shiyu Wang ¹Jianchang Qian ¹Qianwen Zhang ¹Yinshuang Lai ²Huijing Huang ³Jing Yuan ¹Shanxin Li ⁴Min Hui ²Peipei Wang ²Bingbing Chen ¹Zhiguo Liu²

作者信息

1. School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou 325035,China
2. Chemical Biology Research Center at School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou 325035,China
3. Yueqing People's Hospital,Wenzhou 325035,China
4. Department of Pharmacy,Changhai Hospital,Naval Medical University,Shanghai 200433,China
折叠

摘要

关键词

non-small cell lung cancer/curcumin/piperlongumine/resistance/EGFR-TKI/PI3K/AKT pathway

Key words

non-small cell lung cancer/curcumin/piperlongumine/resistance/EGFR-TKI/PI3K/AKT pathway

引用本文复制引用

Shiyu Wang,Jianchang Qian,Qianwen Zhang,Yinshuang Lai,Huijing Huang,Jing Yuan,Shanxin Li,Min Hui,Peipei Wang,Bingbing Chen,Zhiguo Liu..Exploring the antitumor effect of curcumin-piperlongumine hybrid molecule(CP)on EGFR-TKI-resistant non-small cell lung cancer using network pharmacological analysis and experimental verification[J].生物化学与生物物理学报（英文版）,2025,57(11):1803-1813,11.

基金项目

This work was supported by the grants from the National Natural Science Foundation of China(Nos.82203839 and 82273788)and the Natural Science Foundation of Zhejiang Province(No.LQ21H310007). （Nos.82203839 and 82273788）

生物化学与生物物理学报（英文版）

ISSN：1672-9145

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