青岛大学学报（医学版）2025，Vol.61Issue(6)：896-900,5.DOI:10.11712/jms.2096-5532.2025.61.185
ICAS置入Enterprise支架后病情转归影响因素分析
Influencing factors for the prognosis of intracranial atherosclerotic stenosis after Enterprise stent placement
摘要
Abstract
Objective To investigate the influencing factors for early complications and in-stent restenosis(ISR)after En-terprise stent placement in patients with severe intracranial atherosclerotic stenosis(ICAS).Methods A retrospective analysis was performed for the clinical data of 207 patients who underwent Enterprise stent placement due to severe ICAS in Anyang Re-gional Hospital of Puyang City from January 2022 to March 2024.According to the presence or absence of early complications with-in one month after surgery,the patients were divided into complication group and non-complication group,and according to the re-sults of imaging examination at 6 months after surgery,the patients were divided into ISR group and non-ISR group.A multivariate logistic regression analysis was used to identify the risk factors for prognosis.Results The incidence rate of early complications was 9.2％within one month after surgery,and compared with the non-complication group,the complication group had a signifi-cantly higher proportion of patients comorbid with hypertension,coronary heart disease,or diabetes,as well as a significantly lon-ger preoperative stenosis length(x2=4.124-6.725,t=2.076,all P＜0.05).The incidence rate of ISR was 16.9％at 6 months af-ter surgery,and compared with the non-ISR group,the ISR group had a significantly higher level of high-sensitivity C-reactive pro-tein(hs-CRP),a significantly higher rate of postoperative residual stenosis,and a significantly higher proportion of patients with homocysteinemia or stenosis in the intracranial segment of the vertebral artery/basilar artery(x2=4.694,4.970;t=2.855,4.381;all P＜0.05).The multivariate analysis showed that hypertension and diabetes were independent risk factors for early postoperative complications(OR=1.089-3.713,95％CI=0.944-1.253 to 1.257-11.007,all P＜0.05),while hs-CRP,site of stenosis,and the rate of postoperative residual stenosis were independent risk factors for ISR(OR=1.090-2.947,95％CI=0.966-1.273 to 1.157-8.159,all P＜0.05).Conclusion Preoperative hypertension and diabetes are closely associated with the onset of early postoperative complications,while hs-CRP,site of stenosis,and the rate of postoperative residual stenosis are risk factors for the development of ISR after surgery,and therefore,early intervention should be implemented for these conditions in clinical practice.关键词
颅内动脉硬化/缩窄/病理性/自膨胀式金属支架/手术后并发症/支架内再狭窄/影响因素分析Key words
intracranial arteriosclerosis/constriction/pathologic/self expandable metallic stents/postoperative complica-tions/in-stent restenosis/root cause analysis分类
医药卫生引用本文复制引用
李俊青,洪丽,牛艳国..ICAS置入Enterprise支架后病情转归影响因素分析[J].青岛大学学报（医学版）,2025,61(6):896-900,5.基金项目
河南省医学科技攻关计划项目(LHGJ202200331) （LHGJ202200331）
