现代中医药2026，Vol.46Issue(1)：6-13,后插1,9.DOI:10.13424/j.cnki.mtcm.2026.01.002
基于网络药理学和分子对接桑叶降糖作用机理研究
Study on the Hypoglycemic Effect for Mori Folium Based on Network Pharmacology and Molecular Docking
摘要
Abstract
Objective To investigate the potential active ingredients and mechanism of the hypoglycemic effect for Mori Folium with network pharmacology and molecular docking.Methods The active ingredients of Mori Folium were identified through searching relevant literature,and the 67 active ingredients identified were screened according to their gastrointesti-nal absorption and drug-like properties.Then,the screened ingredients were subjected to target prediction,and the inter-sections between the obtained targets and the targets of hypoglycemic drugs in GenneCards database were obtained.The rela-tionships between the intersected targets were examined,and the component-target-pathway relationship diagram was con-structed.At last,the molecular docking prediction of the important active ingredients and targets was carried out.Results There are 10 potential active ingredients with hypoglycemic effects in Mori Folium,namely isomulberry alkaloids,buck-wheat alkaloids,cyclopentanone B2,3-epibuccinine,1-deoxynogirimycin,quercetin,nigella sativa,mulberry piadenone A,and kaempferol,which are involved in a total of 97 potential targets and 84 signaling pathways.The PPI network analy-sis showed that these key targets,such as AKT1,SRC,EGFR,MMP9,PIK3R,KDR,PTK2,MAPT and so on,were the key targets for the treatment of type 2 diabetes mellitus.The analysis of GO function and KEGG pathway revealed that the main metabolic pathways were nitrogen metabolism,galactose metabolism and ovarian steroidogenesis.Molecular docking results showed that the target protein EGFR binds well to the chemical components norartocarpetin,Quercetin and Kaempferol.Conclusion Based on network pharmacology and molecular docking methods,the active components of mul-berry leaves were screened out,and their mechanism of action was preliminarily explored,providing a theoretical basis for further basic researchs.关键词
桑叶/降糖作用/网络药理学/分子对接/作用机理Key words
Mori Folium/hypoglycemic effect/network pharmacology/molecular docking/mechanism分类
医药卫生引用本文复制引用
李沐芷,薛金涛,王蒙蒙,姚梦哲,唐渤皓,张玉环,陈欣,徐亦晴,于家梦,李春燕..基于网络药理学和分子对接桑叶降糖作用机理研究[J].现代中医药,2026,46(1):6-13,后插1,9.基金项目
河南省高等学校重点科研项目(25B360004) （25B360004）
新乡医学院三全学院(豫北医学院)骨干教师培养计划(SQ2025GGJS08) （豫北医学院）
