实用医学杂志2026，Vol.42Issue(2)：255-265,11.DOI:10.3969/j.issn.1006-5725.2026.02.011
针灸对缺血性脑卒中康复患者免疫稳态及生活能力的影响
Effects of acupuncture on immune homeostasis and functional recovery in ischemic stroke rehabilitation patients
摘要
Abstract
Objective To investigate the value of acupuncture therapy in restoring immune homeostasis,reducing the levels of inflammatory markers,and improving the activities of daily living in patients recovering from ischemic stroke.Methods This research is a single-center,randomized controlled clinical trial.A total of 100 patients with ischemic stroke who were undergoing rehabilitation between August 2023 and January 2025 were enrolled.By using a random number table,the participants were randomly allocated to either a rehabilitation control group(n=50),which received integrated Chinese-Western rehabilitation therapy,or an acupuncture experimental group(n=50),which received acupuncture in addition to the standard integrated rehabilitation.The immune parameters(T,B,NK cell counts and CD4+/CD8+ratio),inflammatory markers,Barthel Index(BI),and Fugl-Meyer Assessment(FMA)scores were compared before and after treatment.A cohort of 50 healthy individuals served as the healthy control group for assessing the baseline immune and inflammatory status.Results At baseline,the patient groups exhibited significant immune dysregulation when compared to the healthy control group.This was manifested by lower counts of total T cells,CD4+cells,and CD8+cells,as well as higher levels of B cells and NK cells(P<0.05).After the intervention,the acupuncture experimental group demonstrated a substantial increase in total T cells,CD4+cells,and the CD4+/CD8+ratio.Moreover,there was a more marked reduction in B and NK cell levels in the acupuncture experimental group compared to the rehabilitation control group.Inflammatory markers decreased in both groups after treatment,but the reduction amplitude was significantly greater in the acupuncture experimental group.Similarly,although both groups exhibited enhanced BI and FMA scores before and after treatments,the improvements were statistically more significant in the acupuncture experimental group(P<0.05).The acupuncture group showed significantly higher overall therapeutic efficacy compared to the rehabilitation control group,with overall therapeutic efficacy rates of 96.0%and 72.0%,respectively(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion Adjunctive acupuncture significantly promotes immune rebalancing,alleviates inflammation,and enhances functional independence in rehabilitation patients with ischemic stroke.关键词
缺血性脑卒中/针灸/外周血淋巴细胞亚群/炎症指标/Barthel指数/Fugl-Meyer运动功能评定量表Key words
ischemic stroke/acupuncture/peripheral blood lymphocyte subsets/inflammatory bio-markers/Barthel index/Fugl-Meyer assessment scale分类
医药卫生引用本文复制引用
陶炜,粱士锋,施志农,李珍,王伦善..针灸对缺血性脑卒中康复患者免疫稳态及生活能力的影响[J].实用医学杂志,2026,42(2):255-265,11.基金项目
安徽省高等学校科学研究项目(自然科学类重点项目)(编号:2024AH051887) （自然科学类重点项目）
芜湖市卫健委科研项目(编号:WHWJ2023y070) （编号:WHWJ2023y070）
