实用医学杂志2026，Vol.42Issue(2)：320-326,7.DOI:10.3969/j.issn.1006-5725.2026.02.018
聚桂醇注射联合微波消融与单纯聚桂醇注射对于囊性或囊性为主甲状腺结节的疗效比较
Comparison of the efficacy between lauromacrogol injection combined with microwave ablation and lauro-macrogol injection alone for cystic or predominantly cystic thyroid nodules
摘要
Abstract
Objective Comparison of the treatment efficacy between percutaneous lauromacrogol injection(PLI)combined with microwave ablation(MWA)and PLI alone for cystic or predominantly cystic thyroid nodules.Methods This study retrospectively analyzed 90 cystic or predominantly cystic thyroid nodules that were treated with either PLI or PLI+MWA at Shanghai Ninth People's Hospital from January 2021 to March 2025.All cases were confirmed to be benign through preoperative ultrasound and fine-needle aspiration.The size of the nodules was assessed by ultrasound at 1,3,and 6 months after treatment,and the volume reduction rate(VRR)was calculated.Results A total of 81 patients(90 nodules)were incorporated into the analysis,including 20 males(24 nodules)and 61 females(66 nodules).Among these nodules,59 received PLI treatment,whereas 31 underwent PLI+MWA.Both PLI and PLI+MWA treatments led to a significant reduction in the volume of thyroid nodules.Although the baseline nodule volumes in the PLI+MWA group were larger than those in the PLI group[(17.27±10.49)mL vs.(12.12±11.03)mL,P=0.033],there were no significant differences in nodule volumes between the two groups at 1,3,and 6 months after treatment[(4.02±7.95)mL vs.(7.47±6.93)mL;(2.98±6.31)mL vs.(2.43±2.62)mL;(3.64±8.82)mL vs.(1.09±2.10)mL;all P>0.05].Furthermore,at the 3-month[(14.77±8.48)mL vs.(8.36±9.24)mL,P=0.025]and 6-month[(14.53±6.86)mL vs.(4.79±3.99)mL,P=0.001]follow-ups,the PLI+MWA treatment group showed a significantly greater reduction in nodule volume from the baseline compared to the PLI-only group.One month after treatment,the VRR in the PLI group was higher than that in the PLI+MWA group[83.44%(66.97%,93.07%)vs.52.53%(17.62%,90.66%),P=0.011].However,six months after the operation,the VRR in the PLI+MWA group was significantly higher than that in the PLI group[83.44%(66.97%,93.07%)vs.81.68%(58.43%,96.96%),P=0.019].Moreover,six months after treatment,the cure rate(VRR>90%)in the PLI+MWA group was significantly higher than that in the PLI group(87.5%vs.33.3%,P=0.024).Conclusions Both ultrasound-guided PLI and PLI+MWA are effective therapeutic modalities for benign thyroid nodules with cystic or predominantly cystic components.Significantly,at 6 months after treatment,PLI+MWA yielded notably superior therapeutic outcomes compared to PLI monotherapy.关键词
甲状腺结节/微波消融/聚桂醇注射/结节体积缩小率Key words
thyroid nodules/microwave ablation/percutaneous lauromacrogol injection/volume reduction rate分类
医药卫生引用本文复制引用
陈颖超,陈奕,程静,张雯,夏雯雯,宋怀东,韩兵..聚桂醇注射联合微波消融与单纯聚桂醇注射对于囊性或囊性为主甲状腺结节的疗效比较[J].实用医学杂志,2026,42(2):320-326,7.基金项目
国家自然科学基金项目(编号:82470820) （编号:82470820）
上海交通大学医学院附属第九人民医院管理研究项目(编号:YGB202416) （编号:YGB202416）
上海交通大学医学院附属第九人民医院临床研究助推计划项目(编号:JYLJ202307) （编号:JYLJ202307）
