实用医学杂志2026，Vol.42Issue(2)：342-347,6.DOI:10.3969/j.issn.1006-5725.2026.02.021
妊娠期糖尿病与B族链球菌感染的关联性
A study on the association between gestational diabetes mellitus and group B streptococcus infection
摘要
Abstract
Objective To clarify the clinical characteristics of patients with gestational diabetes mellitus(GDM)complicated by group B streptococcus(GBS)infection and its impact on pregnancy outcomes,and to analyze the predictive value of glycated hemoglobin(HbA1c),neutrophil-to-lymphocyte ratio(NLR),and platelet-to-lymphocyte ratio(PLR)in GDM patients complicated by GBS infection and its complication,chorioamnionitis.Methods A retrospective selection was conducted on 277 inpatients diagnosed with GDM who were admitted to the Nanhai Maternal and Child Health Hospital,Foshan City from January 2023 to December 2024.Among these patients,those with GDM combined with GBS infection were assigned to the positive group(n=75),while those with GDM but without GBS infection were assigned to the control group(n=202).The differences in clinical data,including age,and pregnancy outcomes between the two groups of pregnant women were compared.Multivari-ate logistic regression analysis was employed to explore the risk factors for GBS infection in GDM patients and the risk factors for chorioamnionitis in GDM patients with GBS infection.The predictive value of the relevant indicators was assessed using the receiver operating characteristic curve(ROC).Results In the positive group,the levels of HbA1c,NLR,and PLR were significantly elevated.Moreover,the incidences of premature rupture of membranes and intrauterine distress also showed a significant increase,and these differences were statistically significant(all P<0.05).The results of multivariate logistic regression analysis indicated that HbA1c(OR=2.574,95%CI:1.355～4.889)and NLR(OR=1.545,95%CI:1.318～1.811)were independent risk factors for GBS infection in patients with GDM(all P<0.05).Meanwhile,NLR(OR=1.694,95%CI:1.242～2.190)was identified as an independent risk factor for chorioamnionitis in GDM patients with GBS infection.The ROC curve results demon-strated that the area under the curve(AUC)of the combined prediction model constructed based on HbA1c and NLR for predicting GBS infection in GDM patients was 0.800(95%CI:0.741～0.859),and the AUC of NLR for predicting chorioamnionitis was 0.855(95%CI:0.760～0.951).The PLR had no significant correlation with GBS infection and its complications(P>0.05).Conclusions GBS infection in patients with GDM elevates the risk of adverse pregnancy outcomes among pregnant women.Elevated levels of glycated HbA1c and NLR are independent risk factors for GBS infection in GDM patients.The NLR holds predictive value for chorioamnionitis in GDM patients with GBS infection.It is advisable to enhance the management of high-risk pregnancies to prevent adverse pregnancy outcomes and mitigate the risk of maternal and infant infections during the perinatal period.关键词
妊娠期糖尿病/B族链球菌/妊娠结局/中性粒细胞与淋巴细胞比值/糖化血红蛋白/绒毛膜羊膜炎Key words
gestational diabetes mellitus/group b streptococcus/pregnancy outcome/neutrophil-to-lymphocyte ratio/glyc-ated hemoglobin/chorioamnionitis分类
医药卫生引用本文复制引用
黄柳华,周宁,周子聪,吴清华,肖维威,沈晨光,朱利,赵卫..妊娠期糖尿病与B族链球菌感染的关联性[J].实用医学杂志,2026,42(2):342-347,6.基金项目
国家自然科学基金项目(编号:32370146) （编号:32370146）
广东省科技计划项目(编号:2021B1212030014) （编号:2021B1212030014）
广东省基础与应用基础研究基金项目(编号:2024A1515010995) （编号:2024A1515010995）
广州市基础研究计划项目(编号:2023A03J0810) （编号:2023A03J0810）
