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Crystal structures of Kif2A complexed with WDR5 reveal the structural plasticity of WIN-S7 sites

Yang Yang Shuting Zhang Zhangyu Wu Wenwen Li Xuefang Sun Yumi Xuan Tianrong Hang Li Xu Xuemin Chen

生物化学与生物物理学报（英文版）2025，Vol.57Issue(12)：1999-2010,12.

生物化学与生物物理学报（英文版）2025，Vol.57Issue(12)：1999-2010,12.DOI:10.3724/abbs.2025066

Crystal structures of Kif2A complexed with WDR5 reveal the structural plasticity of WIN-S7 sites

Yang Yang ¹Shuting Zhang ¹Zhangyu Wu ¹Wenwen Li ¹Xuefang Sun ¹Yumi Xuan ²Tianrong Hang ¹Li Xu ³Xuemin Chen¹

作者信息

1. School of Life Sciences,Anhui University,Hefei 230601,China
2. Center for Human Tissues and Organs Degeneration,Faculty of Pharmaceutical Sciences,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 581055,China
3. Institute of Bio-Architecture and Bio-Interactions(IBABI),Shenzhen Medical Academy of Research and Translation(SMART),Shenzhen 518107,China
折叠

摘要

关键词

WDR5/Kif2A/WIN motif/crystal structure/S7 pocket

Key words

WDR5/Kif2A/WIN motif/crystal structure/S7 pocket

引用本文复制引用

Yang Yang,Shuting Zhang,Zhangyu Wu,Wenwen Li,Xuefang Sun,Yumi Xuan,Tianrong Hang,Li Xu,Xuemin Chen..Crystal structures of Kif2A complexed with WDR5 reveal the structural plasticity of WIN-S7 sites[J].生物化学与生物物理学报（英文版）,2025,57(12):1999-2010,12.

基金项目

This work was supported by the grants from the National Natural Science Foundation of China(Nos.32200979,32371270,and 32401018),the Anhui Provincial Natural Science Foundation(No.2208085QC76),the Anhui Province Outstanding Youth Fund(No.2308085Y21)and the Natural Science Research Project of Anhui Educational Committee(No.2022AH030010). （Nos.32200979,32371270,and 32401018）

生物化学与生物物理学报（英文版）

ISSN：1672-9145

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