西安交通大学学报（医学版）2026，Vol.47Issue(1)：48-54,7.DOI:10.7652/jdyxb202601007
淀粉样蛋白相关影像学异常的识别与管理
Identification and management of amyloid-related imaging abnormalities
摘要
Abstract
Amyloid-related imaging abnormalities(ARIAs)are intracranial signal abnormalities observed by magnetic resonance imaging(MRI),and are one of the main adverse events of anti-Aβ monoclonal antibody therapy in Alzheimer's disease(AD).In severe cases,they can endanger the patients' life.ARIA,a common imaging manifestation during AD anti-amyloid immunotherapy,primarily includes two types:amyloid-related imaging abnormalities-edema/effusion(ARIA-E)and amyloid-related imaging abnormalities-hemorrhage/hemosiderin(ARIA-H).The pathophysiological mechanisms of ARIA involve vasogenic edema and cerebral microbleeds triggered by amyloid deposition.With the approval of anti-Aβ monoclonal antibodies in China,clinicians will increasingly encounter ARIA.Early identification and standardized management of ARIA can balance the efficacy and safety of anti-Aβ therapy,providing patients with more optimized individualized treatment strategies.Timely recognition and assessment of ARIA severity during medication use are crucial for clinical decision-making.关键词
阿尔茨海默病(AD)/抗Aβ单克隆抗体/淀粉样蛋白相关影像学异常(ARIA)/磁共振成像(MRI)/风险管理Key words
Alzheimer's disease(AD)/anti-Aβ monoclonal antibody/amyloid-related imaging abnormality(ARIA)/magnetic resonance imaging(MRI)/risk management分类
医药卫生引用本文复制引用
张玉洁,孟新玲..淀粉样蛋白相关影像学异常的识别与管理[J].西安交通大学学报（医学版）,2026,47(1):48-54,7.基金项目
新疆维吾尔自治区2023年第二批"天山英才"培养计划-科技创新领军人才项目(No.20232111643)Supported by the Xinjiang Uygur Autonomous Region's 2023 Second Batch of"Tianshan Talents"Training Program-Leading Talents in Science and Technology Innovation Project(No.20232111643) （No.20232111643）
