西安交通大学学报（医学版）2026，Vol.47Issue(1)：55-61,7.DOI:10.7652/jdyxb202601008
阿尔茨海默病的早期识别和精准诊断
Early identification and precise diagnosis of Alzheimer's disease
摘要
Abstract
Early identification and precise diagnosis of Alzheimer's disease(AD)are crucial for delaying disease progression and optimizing treatment strategies.AD pathology is characterized by core features,including β-amyloid plaque deposition,neurofibrillary tangles,and neurodegeneration.These serve as the fundamental foundation for AD diagnosis.In clinical practice,early identification of AD can be achieved through neuropsychological screening,neuroimaging assessment,detection of cerebrospinal fluid(CSF)/plasma biomarkers(such as the Aβ42/40 ratio and p-Tau),and genetic analysis.Precise diagnosis requires the integration of CSF or peripheral blood biomarkers,neuroimaging features(e.g.,Aβ PET/Tau PET),and clinical symptoms.The combined application of multimodal biomarkers enhances diagnostic accuracy,providing objective basis for the early identification and biological staging of AD.关键词
阿尔茨海默病(AD)/β-淀粉样蛋白沉积/Tau蛋白磷酸化/早期诊断/生物标志物Key words
Alzheimer's disease(AD)/β-amyloid plaque deposition/Tau phosphorylation/early diagnosis/biomarker分类
医药卫生引用本文复制引用
刘碧菡,章军建..阿尔茨海默病的早期识别和精准诊断[J].西安交通大学学报（医学版）,2026,47(1):55-61,7.基金项目
国家自然科学基金资助项目(No.82071210)Supported by the National Natural Science Foundation of China(No.82071210) （No.82071210）
