西安交通大学学报（医学版）2026，Vol.47Issue(1)：109-117,9.DOI:10.7652/jdyxb202601015
甘油三酯-葡萄糖相关指标与颈动脉粥样硬化斑块的相关性分析
Association between triglyceride glucose-related indices and carotid atherosclerostic plaque in people on health examination
摘要
Abstract
Objective To investigate the association between triglyceride glucose(TyG)-related indices and carotid atherosclerotic plaque(CAP),and to evaluate the predictive value of these indices for CAP.Methods A total of 82 674 individuals who underwent health check-ups at the Department of Health Medicine,The First Affiliated Hospital of Xi'an Jiaotong University,from 2019 to 2024 were included.Based on the carotid ultrasound results,they were divided into two groups:CAP group(33 040 cases)and non-CAP group(49 634 cases).TyG index,triglyceride and glucose and body mass index(TyG-BMI),triglyceride and glucose and waist circumference(TyG-WC),triglyceride and glucose and waist-to-height ratio(TyG-WHtR)were included as both continuous and categorical variables in the multivariate Logistic regression models to assess their relationships with CAP.The quartile data of these indices were categorized from low to high into Q1-Q4 groups.Receiver operating characteristic(ROC)curves were plotted to find cut-off values and evaluate the predictive value of TyG-related indices for CAP occurrence.Results When analyzed as continuous variables,TyG,TyG-BMI,TyG-WC,and TyG-WHtR were all positively correlated with CAP with odds ratios(OR)and 95％confidence intervals(95％CI)of 1.148(1.117,1.181),1.009(1.004,1.014),1.004(1.003,1.006),and 1.069(1.04,1.098),respectively(P＜0.05).After categorizing these indices into quartiles(Q1-Q4),their associations with CAP remained statistically significant(OR of Q2-Q4:TyG:1.751,2.312,2.654;TyG-BMI:1.751,2.312,2.654;TyG-WC:1.150,1.300,1.450;TyG-WHtR:1.200,1.400,1.600,all P＜0.05).Among them,TyG-WHtR had the strongest predictive power for CAP,followed by TyG-WC and TyG itself,while TyG-BMI had the weakest predictive power,with the largest area under the ROC curve being 0.633,0.619,0.604,and 0.584,respectively.Conclusion TyG-related indices show a significant positive correlation with the formation of CAP.Among these indices,TyG-WHtR has the highest predictive ability to identify CAP risk.关键词
颈动脉粥样硬化斑块(CAP)/甘油三酯-葡萄糖(TyG)指数/甘油三酯-葡萄糖体质指数(TyG-BMI)/甘油三酯-葡萄糖腰围(TyG-WC)/甘油三酯-葡萄糖腰围身高比(TyG-WHtR)/胰岛素抵抗(IR)分类
医药卫生引用本文复制引用
杨玉环,陈卓,王军,马茂..甘油三酯-葡萄糖相关指标与颈动脉粥样硬化斑块的相关性分析[J].西安交通大学学报（医学版）,2026,47(1):109-117,9.基金项目
陕西省自然科学基金青年项目(No.2019SF-026) （No.2019SF-026）
陕西省自然科学基金面上项目(No.2024SF-YBXM-097) （No.2024SF-YBXM-097）
西安交通大学第一附属医院临床研究项目(No.XJTU1AF2023LSL-019)Supported by the Natural Science Foundation of Shaanxi Province(No.2019SF-026),the Natural Science Foundation of Shaanxi Province(No.2024SF-YBXM-097),and Clinical Research Award of The First Affiliated Hospital of Xi'an Jiaotong University(No.XJTU1AF2023LSL-019) （No.XJTU1AF2023LSL-019）
