畜牧与兽医2026，Vol.58Issue(2)：104-109,6.
高致病性猪繁殖与呼吸综合征活疫苗和猪圆环病毒2型灭活疫苗联合免疫效果的评价
Evaluation on the combined immunization effect of live vaccine for highly pathogenic porcine reproductive and respiratory syndrome and inactivated vaccine for porcine circovirus type 2
摘要
Abstract
To establish a convenient and effective co-immunization method for highly pathogenic porcine reproductive and respiratory syn-drome(HP-PRRS)and porcine circovirus type 2(PCV2),this study evaluated the feasibility of combined vaccination through in vitro cell infection and pig immunization experiments.The test group received a single intramuscular injection of HP-PRRS live vaccine diluted with PCV2 inactivated vaccine,while the control group received separate injections at two sites;and their antibody responses were monitored u-sing commercial ELISA kits.The results showed that the HP-PRRS virus titers remained stable within one hour after mixing.For HP-PRRS antibodies,the test group exhibited faster antibody elevation at 30 days post-immunization,with a significantly higher mean S/P value(2.01)at 60 days,compared with the control group(1.55).For PCV2,the antibody levels increased in both groups,reaching 2.16(the test group)and 2.29(the control group)at 90 days,respectively,with no significant difference(P>0.05).The test group demonstrated more uniform HP-PRRS antibody responses but slightly dispersed PCV2 antibodies.The statistical analysis confirmed no interference in anti-body production between the two vaccines,with comparable efficacy between the groups.This study validated the feasibility of co-administe-ring HP-PRRS live vaccine and PCV2 inactivated vaccine,providing a practical solution for field immunization.关键词
高致病性猪繁殖与呼吸综合征活疫苗/猪圆环病毒2型灭活疫苗/联合免疫/抗体Key words
live vaccine for HP-PRRS/inactivated vaccine for porcine circovirus type 2/combined immunization/antibody分类
农业科技引用本文复制引用
邱冬,陈昌海,闫喜军,刘云,吴坤,徐小艳,任雪枫..高致病性猪繁殖与呼吸综合征活疫苗和猪圆环病毒2型灭活疫苗联合免疫效果的评价[J].畜牧与兽医,2026,58(2):104-109,6.基金项目
江苏现代农业(生猪)产业技术体系疾病防控创新团队项目(JATS[2021]358) （生猪）
江苏现代农业(生猪)产业技术体系疾病防控创新团队项目(JATS[2022]361) （生猪）
