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Longitudinal analysis identifies bystander-activated innate cytotoxic CD8+T cells as predictors and therapeutic biomarkers for acute graft-versus-host disease

Yinchun Chen Yufeng Liu Ruiqing Zhou Limei Zhong Haimei Deng Jun Yu Huijuan Wang Xiaotao Jiang Wenjian Mo Shunqing Wang

微生物与宿主健康（英文）2026，Vol.4Issue(1)：20-40,21.

微生物与宿主健康（英文）2026，Vol.4Issue(1)：20-40,21.DOI:10.1016/j.hlife.2025.10.006

Longitudinal analysis identifies bystander-activated innate cytotoxic CD8+T cells as predictors and therapeutic biomarkers for acute graft-versus-host disease

Yinchun Chen ¹Yufeng Liu ²Ruiqing Zhou ¹Limei Zhong ³Haimei Deng ⁴Jun Yu ⁵Huijuan Wang ⁵Xiaotao Jiang ⁶Wenjian Mo ¹Shunqing Wang¹

作者信息

1. Department of Hematology,Guangzhou First People's Hospital,The Second Affiliated Hospital,School of Medicine,South China University of Technology,Guangdong,China
2. Department of Hematology,Guangzhou First People's Hospital,The Second Affiliated Hospital,School of Medicine,South China University of Technology,Guangdong,China||Center for Medical Research on Innovation and Translation,Guangzhou First People's Hospital,The Second Affiliated Hospital,School of Medicine,South China University of Technology,Guangdong,China
3. Department of Laboratory Medicine,Guangdong Second Provincial General Hospital,Guangdong,China
4. Department of Hematology,The Seventh Affiliated Hospital of Sun Yat-Sen University,Guangdong,China
5. Center for Medical Research on Innovation and Translation,Guangzhou First People's Hospital,The Second Affiliated Hospital,School of Medicine,South China University of Technology,Guangdong,China
6. Department of Gastroenterology,The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangdong,China
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摘要

关键词

acute graft-versus-host disease/biomarkers/bystander-activation/CD38+HLA-DR+CD8+T cells/IL-15/PI3K/mTOR pathway

Key words

acute graft-versus-host disease/biomarkers/bystander-activation/CD38+HLA-DR+CD8+T cells/IL-15/PI3K/mTOR pathway

引用本文复制引用

Yinchun Chen,Yufeng Liu,Ruiqing Zhou,Limei Zhong,Haimei Deng,Jun Yu,Huijuan Wang,Xiaotao Jiang,Wenjian Mo,Shunqing Wang..Longitudinal analysis identifies bystander-activated innate cytotoxic CD8+T cells as predictors and therapeutic biomarkers for acute graft-versus-host disease[J].微生物与宿主健康（英文）,2026,4(1):20-40,21.

基金项目

We thank patients and donors included in the study.This study was supported by the National Key Research and Development Program of China(grant number 2024YFC2510502 to W.S.),the National Natural Science Foundation of China(grant number 8217060280 to L.Y.),the Natural Science Foundation of Guang-dong Province(grant number 2114050002084 to L.Y.),the Inno-vative Clinical Technique of Guangzhou(grant number 2023C-GX01 to W.S.),and the Science and Technology Key Project of Guangzhou(grant numbers 02102010037 to W.S.,SL2024A03J01319 and SL2024A04J00240 to L.Y.). （grant number 2024YFC2510502 to W.S.）

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