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PGRP-SC-mediated innate immune memory against pathogenic bacteria in Drosophila

Zihao Deng Jiyong Liu Jiazhen Luo Yufu Zhang Chen Li Shixin Deng Jiazhi He Zihao He Wenqi Wu Renjie Jiao

微生物与宿主健康（英文）2026，Vol.4Issue(1)：41-55,15.

微生物与宿主健康（英文）2026，Vol.4Issue(1)：41-55,15.DOI:10.1016/j.hlife.2025.09.003

PGRP-SC-mediated innate immune memory against pathogenic bacteria in Drosophila

Zihao Deng ¹Jiyong Liu ¹Jiazhen Luo ¹Yufu Zhang ¹Chen Li ¹Shixin Deng ¹Jiazhi He ¹Zihao He ¹Wenqi Wu ²Renjie Jiao³

作者信息

1. Sino-French Hoffmann Institute,Guangdong Provincial Key Laboratory of Protein Modification and Degradation,School of Basic Medical Science,Guangzhou Medical University,Guangdong,China
2. The Second Affiliated Hospital of Guangzhou Medical University,Guangdong,China
3. Sino-French Hoffmann Institute,Guangdong Provincial Key Laboratory of Protein Modification and Degradation,School of Basic Medical Science,Guangzhou Medical University,Guangdong,China||The Second Affiliated Hospital of Guangzhou Medical University,Guangdong,China
折叠

摘要

关键词

innate immune memory/trained immunity/Drosophila melanogaster/peptidoglycan recognition protein SC(PGRP-SC)/gut/histone H3 lysine 9 trimethylation(H3K9me3)

Key words

innate immune memory/trained immunity/Drosophila melanogaster/peptidoglycan recognition protein SC(PGRP-SC)/gut/histone H3 lysine 9 trimethylation(H3K9me3)

引用本文复制引用

Zihao Deng,Jiyong Liu,Jiazhen Luo,Yufu Zhang,Chen Li,Shixin Deng,Jiazhi He,Zihao He,Wenqi Wu,Renjie Jiao..PGRP-SC-mediated innate immune memory against pathogenic bacteria in Drosophila[J].微生物与宿主健康（英文）,2026,4(1):41-55,15.

基金项目

We thank the Bloomington Drosophila Stock Center(BDSC),Vienna Drosophila Resource Center(VDRC),TsingHua Fly Cen-ter(THFC),and Guangzhou Drosophila Resource Center(GDRC)for providing fly stocks and the China General Microbi-ological Culture Collection Centre(CGMCC)for providing bac-terial stocks.We are grateful to Dr.Dominique Ferrandon for NP1ts-Gal4 flies and PAO1 strain （BDSC）

Dr.Akira Goto for UAS-rpr&hid strains （）

and Dr.Lei Pan for Hml-GenSwitch-Gal4 flies and the Ecc15 strain.This study was funded by the National Key R&D Program of China(grant numbers 2021YFA0805800,2023YFE0107700,and 2020YFA0803202 to R.J.),the 111 Proj-ect(grant number D18010 to R.J.),the National Natural Science Foundation of China(grant number 31970538 to R.J.),the Guangzhou Medical University Discipline Construction Funds(Basic Medicine)(grant number JCXKJS2022A02 to R.J.),the Medical Scientific Research Foundation of Guangdong Prov-ince(grant number A2019292 to J.L.),and the Natural Science Foundation of Guangdong Province(grant number 2017A030310403 to Z.D.). （grant numbers 2021YFA0805800,2023YFE0107700,and 2020YFA0803202 to R.J.）

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