现代技术陶瓷2025，Vol.46Issue(6)：542-568,27.DOI:10.16253/j.cnki.37-1226/tq.2025.06.003
氮化硅生物陶瓷材料的基础与应用研究进展
Fundamentals and Application Research Progress of Silicon Nitride Bioceramic Materials
摘要
Abstract
Silicon nitride(Si3N4)bioceramics exhibit promising potential in bone tissue engineering and implant materials due to their outstanding mechanical properties,biocompatibility,bioactivity,and remarkable antibacterial characteristics.This review systematically summarizes the crystalline phase structure,microstructure,and surface chemical properties of silicon nitride ceramics.It discusses the effects of grain size,grain boundary characteristics,and sintering processes on mechanical strength and toughness,as well as the mechanisms through which surface oxidation and hydrolysis release bioactive compounds such as silicates and ammonia,promoting osteogenesis and inhibiting pathogens.Moreover,composite materials of silicon nitride with graphene,silicon carbide whiskers,and other nanomaterials have significantly improved mechanical performance and have been successfully applied in spinal fusion,hip joint replacement,and dental restoration,demonstrating superior osseointegration,low wear,and excellent antimicrobial effects.However,inherent brittleness and slow degradation rates still limit wider clinical applications.Future research should focus on developing novel silicon nitride composites with graphene and carbon nanotubes to precisely regulate degradation rates,employing artificial intelligence to optimize sintering processes for accurate microstructural control,and conducting multicenter clinical trials to comprehensively evaluate long-term safety and effectiveness,thereby offering more efficient,safe,and reliable solutions for bone defect repair and regenerative medicine.关键词
生物陶瓷/氮化硅/力学性能/生物学性能Key words
bioceramic/silicon nitride/mechanical properties/biological properties分类
化学化工引用本文复制引用
占喆,陈妍如,阿依努尔·阿卜拉,邓斌,宋金柱..氮化硅生物陶瓷材料的基础与应用研究进展[J].现代技术陶瓷,2025,46(6):542-568,27.基金项目
国家自然科学基金(NO.52172133) （NO.52172133）
黑龙江省头雁团队项目(NO.HITTY-20190034). （NO.HITTY-20190034）
