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Virulence arresting drug discovery by strategies targeting bacterial virulence:Mainly focusing on quorum-sensing interference and biofilm inhibition

Lan Lu Yuping Zhang Yulin Zhang Kun Zou Xiaorong Yang Mingxing Li Tianyang Yu Hongping Wang Xingtong Zhu Li Liao Jie Zhu Xiaobo Wang Andi Yang Chen Yang

药物分析学报（英文）2025，Vol.15Issue(12)：2764-2783,20.

药物分析学报（英文）2025，Vol.15Issue(12)：2764-2783,20.DOI:10.1016/j.jpha.2025.101310

Virulence arresting drug discovery by strategies targeting bacterial virulence:Mainly focusing on quorum-sensing interference and biofilm inhibition

Lan Lu ¹Yuping Zhang ¹Yulin Zhang ¹Kun Zou ¹Xiaorong Yang ²Mingxing Li ³Tianyang Yu ¹Hongping Wang ⁴Xingtong Zhu ⁵Li Liao ¹Jie Zhu ¹Xiaobo Wang ⁶Andi Yang ¹Chen Yang¹

作者信息

1. Anti-Infective Agent Creation Engineering Research Centre of Sichuan Province,School of Pharmacy,Chengdu University,Chengdu,610000,China
2. Sichuan Center for Disease Control and Prevention,Chengdu,610041,China
3. Laboratory of Molecular Pharmacology,Department of Pharmacology,School of Pharmacy,Southwest Medical University,Luzhou,Sichuan,646000,China
4. Safety Evaluation Center,Sichuan Institute for Drug Control(Sichuan Testing Center of Medical Devices),Chengdu,610000,China
5. School of Food Science and Biological Engineering,Zhejiang Gongshang University,Hangzhou,310018,Zhejiang,China
6. Hepatobiliary Surgery,Langzhong People's Hospital,Langzhong,Sichuan,637400,China
折叠

摘要

关键词

Virulence arresting drugs/Bacterial virulence factors/Quorum-sensing interference/Biofilm inhibition/Anti-virulence therapy

Key words

Virulence arresting drugs/Bacterial virulence factors/Quorum-sensing interference/Biofilm inhibition/Anti-virulence therapy

引用本文复制引用

Lan Lu,Yuping Zhang,Yulin Zhang,Kun Zou,Xiaorong Yang,Mingxing Li,Tianyang Yu,Hongping Wang,Xingtong Zhu,Li Liao,Jie Zhu,Xiaobo Wang,Andi Yang,Chen Yang..Virulence arresting drug discovery by strategies targeting bacterial virulence:Mainly focusing on quorum-sensing interference and biofilm inhibition[J].药物分析学报（英文）,2025,15(12):2764-2783,20.

基金项目

This work was supported by the National Natural Science Foundation of China(Grant No:82474158)and the Natural Science Foundation of Sichuan Province,China(Grant No.:2024NSFSC0708). （Grant No:82474158）

药物分析学报（英文）

ISSN：2095-1779

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