中国当代儿科杂志2026，Vol.28Issue(1)：30-41,12.DOI:10.7499/j.issn.1008-8830.2503068
先天性心脏病儿童的神经发育评估:基于贝利婴儿发展量表和韦氏智力量表的Meta分析
Neurodevelopmental assessment of children with congenital heart disease:a Meta analysis based on the Bayley Scales of Infant Development and Wechsler Intelligence Scale
摘要
Abstract
Objective To systematically evaluate neurodevelopmental differences between children with congenital heart disease(CHD)and healthy controls.Methods A comprehensive search was conducted in Web of Science,PubMed,Embase,Wanfang Data,China National Knowledge Infrastructure,Chinese Biomedical Literature Service System,and VIP Database to identify studies published from database inception to February 2025 that assessed the neurodevelopment of children with CHD(CHD group)and healthy controls(control group)using the Bayley Scales of Infant Development(BSID)and the Wechsler Intelligence Scale.In total,33 studies involving 3 316 children were included.Hedges'g was used as the effect size.Meta analysis,subgroup analysis,sensitivity analysis,and publication bias analysis were performed using STATA/SE 17.0.Results Based on BSID-II,compared with the control group,the CHD group had significantly lower mental development index(Hedges'g=-1.09)and psychomotor development index(Hedges'g=-1.22)scores(both P<0.001).Based on BSID-III,compared with the control group,the CHD group had markedly lower scores in cognition(Hedges'g=-0.78),language(Hedges'g=-0.65),and motor(Hedges'g=-0.98)(all P<0.001).The Wechsler Intelligence Scale indicated that,compared with the control group,the CHD group had significantly lower full-scale intelligence quotient(Hedges'g=-0.74),verbal intelligence quotient(Hedges'g=-0.86),and performance intelligence quotient(Hedges'g=-0.67)(all P<0.001).Conclusions Children with CHD exhibit developmental delays in cognition,language,motor function,and intelligence.关键词
先天性心脏病/神经发育/贝利婴儿发展量表/韦氏智力量表/儿童Key words
Congenital heart disease/Neurodevelopment/Bayley Scales of Infant Development/Wechsler Intelligence Scale/Child引用本文复制引用
孙梦婷,文宇婷,周成璐,王婷婷,秦家碧,罗曼君,唐嘉鹏,陈烨,陈可彬,邹琪,阮霄睿,彭辕,李詹雯..先天性心脏病儿童的神经发育评估:基于贝利婴儿发展量表和韦氏智力量表的Meta分析[J].中国当代儿科杂志,2026,28(1):30-41,12.基金项目
国家自然科学基金项目(82473644、82404362) （82473644、82404362）
湖南省杰出青年基金项目(2022JJ10087) （2022JJ10087）
2024年度中南大学研究生校企联合创新项目(2024XQLH048) （2024XQLH048）
2025年湖南省研究生科研创新项目(CX20250389、CX20250144). （CX20250389、CX20250144）
