中国当代儿科杂志2026，Vol.28Issue(1)：70-77,8.DOI:10.7499/j.issn.1008-8830.2504183
儿童急性淋巴细胞白血病入住儿童重症监护室的临床特征分析
Clinical characteristics of pediatric patients with acute lymphoblastic leukemia admitted to the pediatric intensive care unit
吴飞凤 1毛珏怡 1万伍卿 1文川1
作者信息
- 1. 中南大学湘雅二医院儿童医学中心,湖南 长沙 410011
- 折叠
摘要
Abstract
Objective To investigate risk factors for pediatric intensive care unit(PICU)admission among children with acute lymphoblastic leukemia(ALL)and risk factors for receipt of life-sustaining therapy(LST)in the PICU.Methods Clinical data of ALL patients treated at the Children's Medical Center of the Second Xiangya Hospital from June 2016 to June 2021 were retrospectively reviewed.Patients were categorized into PICU and non-PICU groups according to PICU admission.Multivariable logistic regression was applied to identify risk factors for PICU admission.The cumulative probability of PICU admission was estimated using Kaplan-Meier curves.PICU patients were further stratified into LST and non-LST groups according to whether LST was received,and multivariable logistic regression was used to identify risk factors for receiving LST.Results A total of 200 children with ALL were included;42(21.0%)were admitted to the PICU at least once,with 48 total admissions.Multivariable logistic regression analysis showed that hyperleukocytosis at diagnosis and lactate dehydrogenase(LDH)>500 U/L were independent risk factors for PICU admission(both P<0.05).Kaplan-Meier curves demonstrated that T-cell ALL and hyperleukocytosis were associated with higher cumulative PICU admission rates.Univariate analysis showed that C-reactive protein,albumin,and respiratory failure were significantly associated with the receipt of LST(all P<0.05).Further multivariable logistic regression analysis revealed that respiratory failure was significantly associated with an increased risk of receiving LST(OR=13.254,P=0.027).Conclusions Children with ALL who have hyperleukocytosis at diagnosis and LDH>500 U/L have a higher risk of PICU admission;respiratory failure is an independent risk factor for receipt of LST among PICU-admitted ALL patients.关键词
急性淋巴细胞白血病/儿童重症监护室/危险因素/儿童Key words
Acute lymphoblastic leukemia/Pediatric intensive care unit/Risk factor/Child引用本文复制引用
吴飞凤,毛珏怡,万伍卿,文川..儿童急性淋巴细胞白血病入住儿童重症监护室的临床特征分析[J].中国当代儿科杂志,2026,28(1):70-77,8.
