中国临床药理学杂志2025，Vol.41Issue(22)：3241-3247,7.DOI:10.13699/j.cnki.1001-6821.2025.22.014
中医药调控线粒体质量控制治疗心脏纤维化的研究现状
Research status of traditional Chinese medicine on mitochondrial quality control in the treatment of cardiac fibrosis
摘要
Abstract
Cardiac fibrosis is a common pathological basis for a variety of cardiovascular diseases,and its core feature is cardiac fibroblast overactivation and extracellular matrix deposition,which ultimately leads to cardiac structural remodeling.Studies have shown that mitochondrial dysfunction is an important driver of the occurrence and development of cardiac fibrosis.Mitochondrial quality control is a set of precise dynamic regulatory systems in cells,involving mitochondrial dynamics,mitochondrial biogenesis and mitochondrial autophagy,which are responsible for maintaining mitochondrial homeostasis.Traditional Chinese medicine has the advantages of multiple pathways,multiple targets and small toxic side effects,and shows great potential in regulating mitochondrial quality control and treating cardiac fibrosis.Based on this,this paper systematically reviews the relationship between mitochondrial quality control and cardiac fibrosis and the mechanism of traditional Chinese medicine to regulate mitochondrial quality control in the treatment of cardiac fibrosis,aiming to provide a theoretical basis and new targets for the clinical treatment of cardiovascular diseases.关键词
中药/心脏纤维化/线粒体质量控制Key words
traditional Chinese medicine/cardiac fibrosis/mitochondrial quality control分类
医药卫生引用本文复制引用
刘杰,金华,杜婕,包璇..中医药调控线粒体质量控制治疗心脏纤维化的研究现状[J].中国临床药理学杂志,2025,41(22):3241-3247,7.基金项目
国家自然科学基金地区基金资助项目(82160886) （82160886）
甘肃省省级重点人才基金资助项目(2023RCXM28) （2023RCXM28）
甘肃省省级科技计划基金资助项目(23JRRA1524) （23JRRA1524）
