中国骨伤2025，Vol.38Issue(12)：1210-1214,5.DOI:10.12200/j.issn.1003-0034.20250812
尿酸钠盐沉积量对痛风患者转化为难治性痛风的预测价值
Predictive value of urate deposition volume for refractory gout development in gout patients
摘要
Abstract
Objective To analyze deposition of sodium urate in patients with gout,and to explore predictive value of sodium urate deposition for the occurrence of refractory gout(RG)by dual-energy CT imaging technique.Methods A retro-spective analysis was conducted on basic data of 176 gout patients admitted from March 2023 to June 2025,including 171 males and 5 females,aged from 22 to 71 years old with an average of(43.16±10.82)years old.According to diagnostic criteria,the patients were divided into RG group and non-RG group.There were 92 patients in RG group,including 90 males and 2 fe-males,aged from 24 to 66 years old with an average of(44.62±11.12)years old;there were 84 patients in non-RG group,in-cluding 81 males and 3 females,aged from 22to71 years old with an average of(41.46±10.31)years old.The courses of hype-ruricemia,uric acid and deposition amounts of monosodium urate(MSU)between two groups were compared.Multivariate Lo-gistic regression was used to analyze influencing factors of RG,receiver operating curve(ROC)was plotted,and area under the curve(AUC)was calculated,in order to evaluate predictive value of MSU deposition for RG.Results The courses of hyperten-sion and hyperuricemia and deposition amount of MSU between two groups were statistically significant(P＜0.05).Logistic analysis reault showed intra-articular MSU deposition[OR=5.402,95％CI(2.095,13.933),P＜0.01],hypertension[OR=2.724,95％CI(1.209,6.134),P＜0.05],courses of hyperuricemia[OR=1.122,95％CI(1.032,1.219),P＜0.01]were independent risk factors for RG.AUC of MSU deposition for predicting RG was 0.824[95％CI(0.763,0.885),P＜0.01],and sensitivity was 63％,specificity was 92.9％,and the optimal cut-off value was 0.410 cm3.Conclusion MSU deposition could increase risk of RG,and the amount of MSU deposition in joint cavity could provide a reference for early identification of patients with RG.关键词
痛风/难治性痛风/双能CT/尿酸钠沉积量Key words
Gout/Refractory gout/Dual-energy CT/Monosodium urate deposition分类
医药卫生引用本文复制引用
谢存香,梅建,侯晓莹,方锦颖,黄怡迪,黄健,叶冠成,王浩,王海隆..尿酸钠盐沉积量对痛风患者转化为难治性痛风的预测价值[J].中国骨伤,2025,38(12):1210-1214,5.基金项目
国家重点研发计划项目(编号:2022YFC3501200,2022YFC3501203) （编号:2022YFC3501200,2022YFC3501203）
国家自然科学基金项目(编号:8237142950)National Key Research and Development Program of China(No.2022YFC3501200,2022YFC3501203) （编号:8237142950）
