中国临床药理学杂志2025，Vol.41Issue(22)：3248-3254,7.DOI:10.13699/j.cnki.1001-6821.2025.22.015
中药调控铁死亡治疗脓毒症心肌病的研究进展
Research progress of traditional Chinese medicine regulating ferroptosis in the treatment of sepsis-induced cardiomyopathy
摘要
Abstract
Sepsis-induced cardiomyopathy is a common cardiovascular complication among septic patients,which significantly increases mortality rates.Ferroptosis is an iron-dependent form of regulated cell death characterized by increased lipid reactive oxygen species(ROS),which causes lipid peroxidation and cell membrane damage.Increasing evidence has highlighted a significant link between ferroptosis and sepsis-induced cardiomyopathy,in which traditional Chinese medicine(TCM)exhibits promising therapeutic potential.This article reviews the mechanism of ferroptosis and current advances in the use of TCM active ingredients and formulated preparations to target ferroptosis in treating sepsis-induced cardiomyopathy,aiming to offer new perspectives for clinical management.关键词
中药/铁死亡/脓毒症心肌病/脓毒症Key words
traditional Chinese medicine/ferroptosis/sepsis-induced cardiomyopathy/sepsis分类
医药卫生引用本文复制引用
王亚运,何天鹏,郭龙飞..中药调控铁死亡治疗脓毒症心肌病的研究进展[J].中国临床药理学杂志,2025,41(22):3248-3254,7.基金项目
甘肃省基金资助项目(22JR11RA250) （22JR11RA250）
陇原青年创新创业人才项目(2024QNGR54) （2024QNGR54）
