中国临床药理学杂志2025，Vol.41Issue(22)：3270-3276,7.DOI:10.13699/j.cnki.1001-6821.2025.22.018
瑞马唑仑防治髋部骨折老年患者围术期神经认知障碍的作用研究进展
Research progress on the role of remazolam in the prevention and treatment of perioperative neurocognitive disorders in elderly patients with hip fracture
摘要
Abstract
Elderly patients with hip fracture have a high incidence of perioperative neurocognitive disorders(PND),poor prognosis and high resource consumption.Remazolam has the pharmacokinetic advantages of esterase metabolism,predictable recovery and hemodynamic friendliness,and can be quickly reversed by flumazenil,making it suitable for people with advanced age,insufficient organ reserve or high risk of cognitive complications.Recent studies have shown that remazolam can reduce the level of postoperative inflammatory markers,improve early cognitive function and reduce the incidence of delirium,while retaining good hemodynamic stability and controllable recovery characteristics.The underlying mechanism involves the inhibition of excessive activation of microglia and neuroinflammatory response,reduction of systemic inflammatory response,reduction of stress and pain intensity,and reduction of cerebral hypoperfusion events and other pathways to produce neuroprotective effects.Therefore,this paper integrates the latest evidence of the molecular mechanism,pharmacological characteristics and clinical application of remazolam in the prevention and treatment of perioperative neurocognitive disorders in elderly patients with hip fracture,and emphasizes its potential value in optimizing perioperative anesthesia management of elderly hip fracture.It is expected to provide a theoretical basis for future high-quality,multi-center,long-term follow-up clinical research,and provide reference for individualized perioperative strategy formulation and PND prevention and treatment.关键词
瑞马唑仑/老年患者/髋部骨折/术后认知功能障碍/术后谵妄Key words
remazolam/elderly patients/hip fracture/postoperative cognitive dysfunction/postoperative delirium分类
医药卫生引用本文复制引用
赵炬仙,张拴军,李雯,王彩红,汪惠文..瑞马唑仑防治髋部骨折老年患者围术期神经认知障碍的作用研究进展[J].中国临床药理学杂志,2025,41(22):3270-3276,7.基金项目
甘肃省自然科学基金资助项目(21JR11RA007、23JRRA540) （21JR11RA007、23JRRA540）
