中国临床药理学与治疗学2025，Vol.30Issue(12)：1587-1595,9.DOI:10.12092/j.issn.1009-2501.2025.12.001
日间过度思睡病因及诊疗现状
Etiology,diagnosis,and current treatment of excessive daytime sleepiness
摘要
Abstract
Excessive daytime sleepiness(EDS)is a clinical condition characterized by an inability to maintain alertness and wakefulness during the day-time,leading to diminished vigilance,impaired day-time functioning,and increased risks of traffic or occupational accidents.The core pathophysiology involves disrupted sleep architecture and dysfunc-tion of brain arousalpromoting systems,which can stem from diverse etiologies including sleep disor-ders,systemic diseases,psychiatric disorders,and medication/substance use.Clinically,high-risk pop-ulations for EDS include occupational drivers and transportation workers,shift workers,individuals with chronic systemic diseases or psychiatric disor-ders,and users of sedative substances.Diagnosis of EDS relies on a detailed medical history and sleep/wake cycle assessment,supplemented by subjec-tive scales(e.g.,Epworth sleepiness scale)and ob-jective tests such as polysomnography(PSG)and the multiple sleep latency test(MSLT).It is crucial to differentiate EDS from fatigue.Currently,there is no universally standardized treatment protocol for EDS.Management focuses on addressing underly-ing causes and alleviating symptoms,often com-bined with wake-promoting agents(WPAs)for suffi-cient therapeutic effect.This article summarizes the etiology,pathophysiological mechanisms,high-risk populations,diagnostic approaches,and cur-rent treatment strategies for EDS.It also proposes future research directions to advance standardized clinical management and promote precision medi-cine in EDS diagnosis and therapy.关键词
日间过度思睡/嗜睡量表/睡眠结构紊乱/评估方法/治疗现状/促觉醒剂Key words
excessive daytime sleepiness/sleepi-ness scales/disrupted sleep architecture/assess-ment methods/current treatment status/wake-pro-moting agents分类
医药卫生引用本文复制引用
李庆云,黄珂..日间过度思睡病因及诊疗现状[J].中国临床药理学与治疗学,2025,30(12):1587-1595,9.基金项目
国家自然科学基金面上项目(82270100) （82270100）
国家自然科学基金项目(82070089) （82070089）
