中国临床药理学与治疗学2025，Vol.30Issue(12)：1606-1614,9.DOI:10.12092/j.issn.1009-2501.2025.12.003
促觉醒药物的研发:过去、现在与未来
The development of wake-promoting agents:past,present and fu-ture
摘要
Abstract
Wake-promoting agents(WPAs)are a class of drugs that primarily excite the cerebral cor-tex,with effects including promoting wakefulness,increasing alertness,enhancing attention,improv-ing cognitive function,and reducing fatigue.The use of WPAs can be traced back hundreds of years,with traditional commonly used WPAs including caf-feine and amphetamine stimulants.However,the contradictions between their efficacy and tolerabili-ty(such as drug dependence and cardiovascular side effects),as well as the clinical limitations of in-sufficient efficacy for excessive daytime sleepiness(EDS)in specific etiologies(such as narcolepsy),have driven the development of novel WPAs.Com-pared to traditional drugs,novel WPAs such as modafinil,solriamfetol,and pitolisant have become important breakthroughs in this field due to their safety advantages.The discovery of orexin receptor agonists has also opened new directions for WPA development.This article reviews the past,pres-ent,and future of WPA development,aiming to provide a reference basis for formulating individual-ized treatment plans in clinical practice.关键词
促觉醒药物/研发/发作性睡病/阻塞性睡眠呼吸暂停/发展历程Key words
wake-promoting agents/develop-ment/narcolepsy/obstructive sleep apnea/evolu-tion分类
医药卫生引用本文复制引用
吴惠涓,赵忠新..促觉醒药物的研发:过去、现在与未来[J].中国临床药理学与治疗学,2025,30(12):1606-1614,9.基金项目
上海市自然科学基金(19ZR1457000) （19ZR1457000）
