中国兽医杂志2026，Vol.62Issue(1)：71-78,8.DOI:10.20157/j.cnki.zgsyzz.2026.01.009
莫昔克丁浇泼剂对猪的安全性及对猪疥螨的驱治效果
Safety and Efficacy of Moxidectin Pour-On Formulation in Pigs Against Sarcoptes scabiei
邓梦梦 1陈国庆 1谢等龙 1张璐 2程阳颖 1齐雪佳 1张燕 1李世杰 1曹兴元2
作者信息
- 1. 浙江海正动物保健品有限公司,浙江 杭州 311400
- 2. 中国农业大学动物医学院,北京 海淀 100193
- 折叠
摘要
Abstract
To evaluate the safety and therapeutic efficacy of moxidectin pour-on formulation against Sarcoptes scabiei infection in pigs,32 three-way crossbred pigs were randomly divided into four groups(n=8 per group).Three groups received moxidectin pour-on at doses of 2.5,7.5,and 12.5 mg/(kg·bw·d)once daily for 3 consecutive days,while the Blank control group received physiological saline.Clinical signs,body temperature,heart rate,respiratory rate,weight gain,and feed conversion rate were recorded.Hematological and serum biochemical parameters were also measured to evaluate safety.Subsequently,a survey of S.scabiei infection was conducted across 12 small-to-medium pig farms in four regions in China.A total of 36 pigs positive for S.scabiei were randomly allocated into six groups(n=6).Five groups were treated with moxidectin pour-on at doses of 0.25,0.5,1,2,and 5 mg/(kg·bw·d),respectively,and the Untreated infection control group received saline.Clinical observations,body weight gain,and cure rates were recorded to determine the optimal dose.Then,24 infected pigs were divided into four groups(n=6):two moxidectin groups[0.5 and 1 mg/(kg·bw·d)],one group treated with a 1 mg/(kg·bw·d)transdermal formulation of abamectin,and one untreated infected control.Weight gain and cure rates were assessed to compare therapeutic efficacy.Safety evaluation showed no abnormal clinical signs,hematological or biochemical changes across all moxidectin dose groups,and no significant difference in weight gain or feed conversion rate compared with the Blank control group(P>0.05),indicating no toxicity within the tested dose range.The infection rate of S.scabiei across 12 farms was 14.38%(65/452).Dose-finding results showed all pigs treated with doses≥0.5 mg/(kg·bw·d)achieved 100%cure rates;only two pigs in the 0.25 mg/(kg·bw·d)group still showed mites.Weight gain did not differ significantly among treated groups(P>0.05),but pigs in the 1 mg/(kg·bw·d)group gained significantly more weight than Untreated infection control group(P<0.05).In efficacy comparison,both moxidectin groups[0.5 and 1 mg/(kg·bw·d)]and the Abamectin transdermal group achieved 100%cure rates,with significantly greater weight gain than Untreated infection control group(P<0.05).This study determined that 0.5 mg/(kg·bw·d)is a safe and effective dose of moxidectin pour-on formulation for treating pig S.scabiei infection,offering a new administration route and treatment protocol for clinical application.关键词
莫昔克丁/浇泼剂/安全性/猪疥螨/驱治效果Key words
moxidectin/pour-on formulation/safety/Sarcoptes scabiei in pigs/efficacy分类
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邓梦梦,陈国庆,谢等龙,张璐,程阳颖,齐雪佳,张燕,李世杰,曹兴元..莫昔克丁浇泼剂对猪的安全性及对猪疥螨的驱治效果[J].中国兽医杂志,2026,62(1):71-78,8.
