中国医科大学学报2026，Vol.55Issue(1)：80-84,5.DOI:10.12007/j.issn.0258-4646.2026.01.014
溶酶体调控骨稳态的作用与机制的研究进展
Research progress on the role and mechanism of lysosomes in regulating bone homeostasis
摘要
Abstract
The skeletal system is highly sensitive to mechanical stimulation and hormonal fluctuations,and its growth and maintenance are in a state of dynamic equilibrium.Under physiological conditions,the skeletal tissue maintains bone homeostasis,a balance between bone resorption and formation,to ensure structural and functional integrity.The relative stability of the internal environment is regulated by dynamic remodeling of the skeletal system.Lysosomes are key organelles that not only mediate autophagy to degrade proteins and dama-ged organelles,but also respond to nutrient signals and help maintain cellular homeostasis.They regulate the functions of bone marrow mesenchymal stem cells,osteoblasts,and osteoclasts through multiple pathways,including autophagy,exocytosis,and calcium signaling to maintain a balance between bone formation and resorption.关键词
溶酶体/自噬/骨髓间充质干细胞/成骨细胞/破骨细胞/骨稳态Key words
lysosome/autophagy/bone marrow mesenchymal stem cell/osteoblast/osteoclast/bone homeostasis分类
医药卫生引用本文复制引用
马铭辰,王贺石,刘尧,赵宝红..溶酶体调控骨稳态的作用与机制的研究进展[J].中国医科大学学报,2026,55(1):80-84,5.基金项目
国家自然科学基金(82071151) （82071151）
辽宁省重点研发项目(2024JH2/102500011) （2024JH2/102500011）
