中国农业大学学报2026，Vol.31Issue(1)：1-10,10.DOI:10.11841/j.issn.1007-4333.2026.01.01
真菌Ndt80-like蛋白研究进展
Recent advances on fungal Ndt80-like proteins
摘要
Abstract
To gain a comprehensive understanding of Ndt80-like protein functions and explore their potential as targets for antifungal drug development,a systematic literature search was conducted in this study by taking the keywords"Ndt80""Ndt80-like protein"and"fungi".The structure of Ndt80-like proteins and their roles in sexual reproduction,meiosis,environmental nutrient sensing,and cellular metabolic remodeling were summarized.The feasibility of developing antifungal drugs targeting these proteins was assessed.The results show that:1)The DNA-binding domains of Ndt80-like proteins are highly conserved in both Ascomycetes and Basidiomycetes,while their activation domains are highly variable.2)Ndt80-like proteins are the key transcriptional activators that regulate sexual reproduction and meiosis in fungi.3)These proteins integrate multiple nutrient signals to modulate fungal development and environmental adaptation.In summary,the fungal Ndt80-like proteins,as members of the p53-like superfamily of transcription factors,play a central role in regulating fungal sexual reproduction,growth and development,metabolic remodeling,environmental stress responses,and pathogenicity.They hold significant application potential for fungal disease control and the development of highly efficient industrial chassis strains.关键词
Ndt80-like蛋白/Ndt80/VIB-1/FSD-1/真菌Key words
Ndt80-like protein/Ndt80/VIB-1/FSD-1/fungi分类
生物科学引用本文复制引用
谢靖,张钦,刘欢,王颖,何群..真菌Ndt80-like蛋白研究进展[J].中国农业大学学报,2026,31(1):1-10,10.基金项目
国家重点研发计划(2018YFA0900500) （2018YFA0900500）
