中国中医基础医学杂志2026，Vol.32Issue(1)：154-161,8.
小儿风热清合剂(口服液)对幼年大鼠的安全性评价研究
Safety Evaluation of Xiao'er Fengreqing Oral Liquid in Juvenile Rats
摘要
Abstract
Objective To evaluate the safety of Xiao'er Fengreqing by acute toxicity test and repeated toxicity test in juvenile SD rats.Methods In the acute toxicity test,the maximum dose(120 g/kg)was used to observe the toxic reaction in rats.The toxicity test of repeated administration was divided into three groups:low,middle,and high Xiao'er Fengreqing group(12 g/kg、30 g/kg、60 g/kg).The juvenile rats were given gastric gavage continuously for 30 days,and the recovery period was 3 weeks,the indexes included general state,body weight,organ coefficient,hematological index,blood biochemical index,hormone index,and pathological section.Results In the acute toxicity test,there were no obvious toxic or side effects related to the tested drug at the dose of 120 g/kg.In the repeated dose toxicity test,there were no obvious toxic changes related to the tested drugs.Conclusion Xiao'er Fengreqing showed no obvious acute toxicity in juvenile rats at a dose of 120 g/kg(equivalent to 100 times the clinical dose),and no obvious toxic reactions were observed after repeated administration for 30 days at a dose of 30 g/kg(equivalent to 25 times the clinical dose).关键词
小儿风热清/幼年大鼠/急性毒性/重复给药毒性/安全性评价Key words
Xiao'er Fengreqing/Juvenile rats/Acute toxicity/Repeated dose toxicity/Safety evaluation分类
医药卫生引用本文复制引用
李洋,刘妍,宋志前,殷苗苗,田子琦,刘晓宁,王淳,宁张弛..小儿风热清合剂(口服液)对幼年大鼠的安全性评价研究[J].中国中医基础医学杂志,2026,32(1):154-161,8.基金项目
河北省重点研发计划项目(22372501D) （22372501D）
河北省重大科技支撑计划项目(242G2503Z) （242G2503Z）
邯郸市科学技术研究与发展计划项目(23313014008) （23313014008）
